The Phenylacetyl-CoA Catabolon
Bibliographic record
Abstract
The phenylacetyl-CoA catabolon is a complex degradative unit integrated by several catabolic pathways that transform different unrelated aromatic compounds (i.e., phenylacetic acid [PhAc], phenylacetaldehyde, styrene, tropic acid, 2-phenylethylamine, 2-phenylethanol, ethylbenzene, penylacetylamides and other esters, n-phenylalkanoates with an even number of carbon atoms) into general metabolites. This supracatabolic unit contains (1) a central pathway (catabolon core or route of convergence) that catalyzes the conversion of PhAc via phenylacetyl-CoA, into TCA intermediates, and (2) different peripheral routes (upper pathways) that are specifically involved in the conversion of different molecules into phenylacetic acid or into phenylacetyl-CoA. The phenylacetyl CoA catabolon, which has important biotechnological applications (enzymatic synthesis of penicillins, aromatic biotransformations, synthesis of new bioplastics, biosensor design, synthesis of drug vehicles, etc.), has been described in different nonphylogenetically related microbes, reinforcing the metabolic and industrial importance of this complex pathway.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".