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Record W2487280320 · doi:10.21767/2254-6081.100082

Elimination of Frequency Modulated Magnetic Field Suppression of Melanoma Cell Proliferation by Simultaneous Exposure to a Pattern Associated With Memory in Mammals

2016· article· en· W2487280320 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueArchives in Cancer Research · 2016
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicElectromagnetic Fields and Biological Effects
Canadian institutionsLaurentian University
Fundersnot available
KeywordsMelanomaCell growthCellField (mathematics)BiologyNeuroscienceCancer researchMedicineCell biologyMathematicsGenetics

Abstract

fetched live from OpenAlex

Strategic whole body application of physiologicallypatterned, weak magnetic fields has been evolving as a third option to treat cancer. Unlike chemical therapies and ionizing radiation physiologically-patterned magnetic fields diminish the growth of only malignant cells but not normal cells. In addition these fields provide some analgesic relief. To discern if competing magnetic fields might abolish the beneficial effects mouse melanoma cells in culture were exposed for 1 hour per day for 5 days to decelerating frequency modulated patterned magnetic fields that are well known for their growth suppressive effects mediated by T-Type calcium channels. Typical suppression rates were obtained. Exposure to a second pattern that evokes LTP (long term potentiation) in hippocampal slices and is the primary physical correlate of memory, produced minimal effects. However when the effective daily frequency-modulated hourly exposures were preceded by only 30 min of LTP patterned magnetic fields the growth suppression effects were completely abolished. These results indicate certain patterned fields cancel the beneficial effects and that the processes that underlie proliferation of malignant cells and memory consolidation in nervous tissue may share characteristics.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.059
Threshold uncertainty score0.221

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.290
Teacher spread0.279 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it