◾ Regulation of Eukaryotic Aquaporins
Bibliographic record
Abstract
Membrane-bound water channels known as aquaporins (AQPs) facilitate water transport across biological membranes along osmotic gradients. Since all living cells depend on their ability to maintain water homeostasis, this must be tightly regulated. In eukaryotes, this is achieved by gating, which involves a conformational change of the CONTENTS Abstract 53 4.1 Introduction 54 4.2AQP Gating 55 4.2.1Gating of Plant AQPs 56 4.2.1.1PIP Gating Mechanism 56 4.2.2Gating of Yeast AQPs 58 4.2.2.1Gating Mechanism of Aqy1 59 4.2.3Gating of Mammalian AQPs 59 4.2.3.1Gating of AQP0 60 4.2.3.2Are Other Mammalian AQPs Gated? 61 4.3AQP Tra cking 62 4.3.1Tra cking of Mammalian AQPs 62 4.3.1.1Tra cking of AQP2 62 4.3.1.2Tra cking of Other Mammalian AQPs 66 4.3.2Tra cking of Plant AQPs 67 4.4Common Structural emes in Regulated AQPs68 4.4.1AQP Gating Involves a Cytoplasmic Constriction Site 68 4.4.2N-Termini Adopt Two Conformations 68 4.4.3Binding of Ca2+ 70 4.5 Conclusion 70 References 71 protein, thereby physically blocking water transport, or by tra cking in which AQPs are shuttled between intracellular storage sites and the plasma membrane.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.005 | 0.004 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".