Development of Micropropagation Technologies for St. John's wort (<i>Hypericum perforaturm L.</i>): Relevance on Application
Bibliographic record
Abstract
Introduction Phytopharmaceuticals are medicinal plant preparations with a long history of anecdotal evidence of efficacy, extensive biochemical characterizations, proven effectiveness in placebo-controlled clinical trials and in some cases, standardization and sale with a Drug Identification Number (DIN). Hypericum perforatum (St. John's wort) is a medicinal plant with a long history of use for the treatment of neurological disorders and depression ( 1, 2, 3, 4 ). In 1998, 7.5 million Americans used St. John's wort for the treatment of neurological disorders and depression ( 5 ) based on a demonstrated efficacy in numerous clinical trials ( 3 ). In 1997, the National Institute of Health (NIH), Office of Alternative Medicines, began a 3-year-study costing $4.3 million to compare the effects of H. perforatum, a placebo and a standard anti-depressive drug in patients suffering from mild depression ( 6 ). Regardless of the outcome of the NIH study, it will be necessary to solve several ongoing problems with preparations
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.017 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".