MétaCan
Menu
Back to cohort
Record W2495888140 · doi:10.1007/978-1-60761-292-6_14

Microglia from Progenitor Cells in Mouse Neopallium

2009· book-chapter· en· W2495888140 on OpenAlex
S. Fedoroff, Arleen Richardson

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueSpringer protocols handbooks/Springer protocols · 2009
Typebook-chapter
Languageen
FieldNeuroscience
TopicNeuroinflammation and Neurodegeneration Mechanisms
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsMicrogliaProgenitor cellCytokineCell biologyBiologyCell cultureNeuroscienceImmunologyStem cellInflammationGenetics

Abstract

fetched live from OpenAlex

This chapter outlines a procedure for initiation of mouse neopallium (cerebral cortex and its underlying white matter) cell cultures and their development into nearly pure microglia cultures. The cytokine CSF-1 is required for the development, survival, and differentiation of microglia. In cultures, astroglia secrete CSF-1 into the medium (Hao et al. 1990, J. Neurosci. Res. 27, 314–323). Therefore, a simple protocol is described, originally developed by 12 (Hao et al. 1991, Int J. Dev. Neurosci. 9, 1–14), which utilizes CSF-1-secreting astroglia cultures for production of better than 99% pure cultures of microglia.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Scholarly communication, Research integrity, Insufficient payload (model declined to judge)
Consensus categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Protocol · Consensus signal: Protocol
Teacher disagreement score0.328
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0020.002
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0010.000
Science and technology studies0.0000.000
Scholarly communication0.0010.001
Open science0.0020.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0020.003

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.055
GPT teacher head0.291
Teacher spread0.236 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it