[PP.12.20] THE IMPACT OF COMBINED ANTIHYPERTENSIVE THERAPY WITH PERINDOPRIL A AND INDAPAMIDE ON MORPHOFUNCTIONAL PARAMETERS OF SMALL AND MEDIUM VESSELS IN PATIENTS WITH ARTERIAL HYPERTENSION
Bibliographic record
Abstract
Objective: Assess the impact of combined therapy with Perindopril A and Indopamide on cognitive function and microcirculation in patients with arterial hypertension (AH). Design and method: 30 patients with AH II-III degree (20 women, 10 men) at the age of 40–70 years old (average age 60,06+10,19 years) were included in the study; the average duration of AH - 14,7 (3;32) years. All patients underwent assessment of endothelial function using photoplethysmography (PPG) (“Angioscan-01”, Angioscan, Russia) and reactive hyperemia test (RHT) (pressurization of air to the cuff at 220 mmHg for 5 minutes). The pulse wave amplitude was identified; according to the augmentation of pulse wave occlusion index (OI), which characterizes endothelial function, was calculated (N>1.8). The reflection index (RI), a parameter of arterioles’ remodeling, was also identified. Structural and functional features of capillary net of finger skin were assessed, using computer video cappilaroscopy of finger skin (CS) (“Capillaroscan-1”, New energetic technologies, Russia). Structural parameters were identified: rest capillary net density (CNDr), CND after venous occlusion test (DCNvo). Functional parameters were identified: CND after RHT (DCNrh), percentage of capillary recovery (PCR), percentage of perfused capillaries (PPC). In all patients cognitive function was assessed by Montreal Scale of cognitive disorders (MSCD) at the beginning and after 12 months. Results: This study allowed us to reveal positive impact of Noliprel-Bi-Forte among patients with AH after 12 month therapy on endothelial function of the microcirculation vessels and small or medium-size arterial vessels: increase of OI 1.4 to 1.8 (p 0.00005), phase displacement increased 5.0 to 10.8 (p 0.00001), what characterizes the improvement of vessel wall elasticity and endothelium dependent vasodilatation. Positive impact of Noliprel-Bi-Forte therapy was noted relatively the parameters of capillary vessel remodeling: DCNr increased 44.8 to 52.0 cap/mm2 (p 0.00007) and DCNvo increased 55.0 to 61.0 cap/mm2 (p 0.006). In the research group statistically significant improvement of cognitive function was also revealed: increase of MSCD points 23 to 27 (p 0.0001). Conclusions: Combination therapy of perindopril A and indapamide improves endothelial function, structural and functional parameters of microcirculation and cognitive function in arterial hypertensive patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.016 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".