[PP.17.16] CORRELATION OF DIPPING STATUS TO MILD COGNITIVE IMPAIRMENT IN HYPERTENSIVE PATIENTS
Bibliographic record
Abstract
Objective: Poorly controlled blood pressure is a risk factor for the development of mild cognitive impairment (MCI). It is still unclear whether the circadian rhythm plays any role for the incidence of MCI and precisely what. Design and method: This is a cross-sectional study of 439 hypertensive patients. The mean age was 64.65 ± 10.15 years; males 160 (36.4%); females 279 (63.6%). The mean hypertension history was 11.10 ± 9.34 years. All were on combination medical therapy. The patients underwent full medical history, physical examination, laboratory screening, ECG, echocardiography, home and office blood pressure measurement, ambulatory blood pressure monitoring (ABPM), and cardio-vascular risk assessment. The neuropsychological screening for MCI was conducted via Montreal Cognitive Assessment (MoCA) and Mini Mental State Examination (MMSE). Geriatric depression scale (GDS) and the 4IADL were also applied. SPSS19 was used for the statistical analysis. Results: The mean result for MoCA was 24.49 ± 3.5 and for MMSE – 27.94 ± 2.1 points. The mean values for the home measured blood pressure were 142.37 ± 17.72 mmHg for the systolic and 84.89 ± 10.43 mmHg for the diastolic. The mean values for the office blood pressure were 146.23 ± 22.35 mmHg for the systolic and 86.61 ± 11.71 mmHg for the diastolic. The mean results from the ABPM were above the recommended values both for the systolic, diastolic, day and night period. The dipping status was defined according the guidelines. The dippers were 151(34.40%); non-dippers – 174(40%); extreme dippers – 27(6.15%); reverse dippers – 90(20.50%). The dippers had higher (p = 0.005) MMSE score (28.38 ± 1.66) than non-dippers (27.74 ± 2.3), as well as than reverse dippers (27.52 ± 2.27 for MMSE, p = 0.001). The difference in the neuropsychological tests’ results between the groups of non-dippers, reverse dippers and extreme dippers was not significant. Conclusions: Abnormal circadian rhythm is a risk factor for MCI in hypertensive patients with multiple risk factors. It may also be a clinical manifestation of hypertensive target-organ damage of the brain.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.063 | 0.017 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".