Persistent PAR2 vasodilation in hypertensive mice
Bibliographic record
Abstract
Proteinase‐Activated Receptor 2 (PAR2) caused vasodilations that were preserved in genetic hypertensive mice. In the current study we examined the effects of infusion of angiotensin II (AII) on PAR2‐mediated vascular smooth muscle relaxations and PAR2 expression on high salt diet‐induced hypertension in mice. Wire myographs were used to measure PAR2 and acetylcholine‐induced relaxations of mesenteric arteries from saline‐treated and AII‐treated mice. PAR2 relaxations persisted in the AII‐treated mice despite the reduction of acetylcholine‐induced relaxation. Blood pressures measured by radiotelemetry determined the severity of hypertension in background and PAR2 knockout mice fed high salt diets over a two week period. Baseline blood pressures and high salt diet‐induced increases in blood pressure in controls were similar to PAR2 knockout mice. We conclude that PAR2 expression did not affect blood pressure response to a high salt diet and therefore, PAR2 expression did not play a role in the blood pressure‐natriuresis relationship. Further investigation is warranted to investigate the interactions of PAR2 with endothelial dysfunction‐resistant mechanisms of vascular smooth muscle relaxation in cardiovascular diseases such as hypertension.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".