Seipin is required for converting nascent to mature lipid droplets
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No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
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- Teacher spread
- 0.242 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
and human cells, we show here that seipin, an ER protein implicated in LD biology, mediates a discrete step in LD formation-the conversion of small, nascent LDs to larger, mature LDs. Seipin forms discrete and dynamic foci in the ER that interact with nascent LDs to enable their growth. In the absence of seipin, numerous small, nascent LDs accumulate near the ER and most often fail to grow. Those that do grow prematurely acquire lipid synthesis enzymes and undergo expansion, eventually leading to the giant LDs characteristic of seipin deficiency. Our studies identify a discrete step of LD formation, namely the conversion of nascent LDs to mature LDs, and define a molecular role for seipin in this process, most likely by acting at ER-LD contact sites to enable lipid transfer to nascent LDs.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- eLife
- Topic
- Lipid metabolism and biosynthesis
- Field
- Biochemistry, Genetics and Molecular Biology
- Canadian institutions
- —
- Funders
- National Institute of General Medical SciencesNational Institutes of HealthWellcome TrustCarnegie Mellon UniversityVillum FondenHoward Hughes Medical InstituteBiogenChinese Academy of SciencesCanadian Institutes of Health ResearchWellcomeEuropean Molecular Biology OrganizationNIHR Cambridge Biomedical Research CentreStrategiske ForskningsrådG. Harold and Leila Y. Mathers Charitable Foundation
- Keywords
- Lipid dropletBiologyComputational biologyCell biologyChemistry
- Has abstract in OpenAlex
- yes