Extremely Small Iron Oxide Nanoparticles Stabilized with Catechol‐Functionalized Multidentate Block Copolymer for Enhanced MRI
Bibliographic record
Abstract
Abstract An effective mussel‐inspired multidentate block copolymer strategy having pendant anchoring catechol groups (Cat‐MDBC) to stabilize extremely small iron oxide nanoparticles (ESNPs) in water is reported. The resultant aqueous Cat‐MDBC/ESNP colloids with diameter ≈16 nm and core diameter ≈2 nm were non‐toxic to cells up to 200 μg/mL and exhibit excellent colloidal stability in physiological condition (pH=7) as well as in the presence of IgG model protein. More promisingly, they had the relaxivity ratio to be r 2 /r 1 =1.5, which is significantly lower than PEG‐coated SNPs with core diameter=1.5‐6 nm; further which is similar to those of Gd‐DOTA T 1 ‐weighted contrast agents. These results suggest that aqueous Cat‐MDBC/ESNP colloids could be a promising candidate for T 1 ‐weighted MRI contrast enhancement.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".