Long term 99Tc-MDP treatment is safe and avoids or prevents or delay total hip arthroplasty for patients with osteonecrosis of the femoral head
Bibliographic record
Abstract
600 Objectives Osteonecrosis of the femoral head (ONFH) is frequently observed in relatively young adults, which has a major impact on lifestyle, and its management remains controversial. Objective To assess the effects of 99Tc-MDP (Yunke) treatment on ONFH. Methods Patients with symptomatic ONFH who failed conservative treatments, refused to or were not suitable for surgery were included and treated with long term 99Tc-MDP. All patients had 99mTc-MDP whole body scan before treatment. They were evaluated by the Short Form 36 (SF-36), the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index at baseline and last follow-up. Radiographic changes according to the Association Research Circulation Osseuse (ARCO) staging were also assessed at baseline and last follow-up. The cumulative incidence of total hip arthroplasty (THA) in patients with ONFH was also determined. At each study site, a treating physician reviewed the clinical laboratory results including blood routine, liver and kidney function before and after treatments to evaluate adverse events of 99Tc-MDP. Results Twenty patients with 30 hips (4 males and 16 females) were included. All patients had increased 99mTc-MDP uptake. The long term 99Tc-MDP treatment significantly improves the quality of life of patients with ONFH by SF-36. At the last follow up, the pain, stiffness and joint function of WOMAC score improved significantly from 26.2±25.99, 2.7±4.0 and 51.8±24.76 to 14.4±28.51, 1.3±2.750 and 24.6±19.77 (p Conclusions Our results suggest that 99Tc-MDP treatment is safe, effective for avoiding or preventing or delaying the need the requirement for THA in young patients with ONFH, patients who refuse to THA and were not suitable for surgery. 99Tc-MDP may have limited effects on advanced ONFH caused by femoral neck fracture. Prospective study on the effects of 99Tc-MDP treatment for patients with different causes of ONFH, multi-dose administration of 99Tc-MDP and the mechanism by which 99Tc-MDP differs from other bisphosphonates in the treatment of OFH awaits further studies.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".