Respirable Bacteriophage Aerosols for the Prevention and Treatment of Tuberculosis
Bibliographic record
Abstract
This chapter discusses the general question of if and how respirable bacteriophages could be used therapeutically for tuberculosis infections. The ongoing accumulation of clinically prevalent antibiotic-resistant strains of Mycobacterium tuberculosis and the difficulties encountered in treating patients with multidrug- and extensively drug-resistant strains, alternative therapies warrant consideration. Bacteriophages are viruses that infect bacterial hosts.Their host-range differ for each phage isolate, but typically narrow, sometimes constrained to one or a few strains within a bacterial species. It is relatively unusual for phages to infect hosts within more than one genus. This typically occurs only when the genera are very closely related. The chapter discusses the mycobacteriophages, which are bacteriophages that infect hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. It reviews the basic aspects of bacteriophages. The chapter considers the availability and features of mycobacteriophages with therapeutic potential. It also considers ways in which these phages might be manufactured as an inhaled pharmaceutical aerosol.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.012 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".