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Sneezing Triggered by Onabotulinum Toxin Injections (P2.262)

2016· article· en· W2513472194 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueNeurology · 2016
Typearticle
Languageen
FieldMedicine
TopicBiomedical Research and Pathophysiology
Canadian institutionsFraser Health
Fundersnot available
KeywordsMedicine

Abstract

fetched live from OpenAlex

Objective: To describe the occurrence of sneezing in a subpopulation of patients injected in the forehead with Onabotulinum toxin for either migraine or essential blepharospasm. Background: Sneezing is commonly triggered by dust, environmental allergens and respiratory tract infections. Some uncommon phenomena that trigger sneezing include light, stomach filling, orgasm and even sexual thoughts alone. Reports exist of lateral medullary stroke and tumours resulting in the loss of the sneezing reflex. It is well known in several reports that eyelid injections can trigger sneezing but we describe 11 cases where only forehead injections trigger a sneezing response. Design/Methods: Retrospective review of 9 cases Results: 9 patients, 4 with BEB and 5 with migraine sneeze with every forehead injection but not those in the eyelids. Conclusions: Clinicians should be aware that injection of onabotulinum can trigger a sneezing response due to afferent stimulation through V1 trigeminal afferents and that the effector of this response is likely centered in the lateral medulla.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.879
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.019
GPT teacher head0.296
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it