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Record W2513658361 · doi:10.4052/tigg.12.7

A Holistic Approach to Glycolipid Function. Is the Lipid Moiety Important?

2000· article· en· W2513658361 on OpenAlexaff
Clifford A. Lingwood

Bibliographic record

VenueTrends in Glycoscience and Glycotechnology · 2000
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGlycosylation and Glycoproteins Research
Canadian institutionsHospital for Sick Children
Fundersnot available
KeywordsGlycolipidMoietyFunction (biology)ChemistryBiochemistryCell biologyComputational biologyStereochemistryBiology

Abstract

fetched live from OpenAlex

精製されているはずの糖脂質を薄層クロマトグラフィーで調べると、2つとか3つのバンドに分かれてしまうことがよくあるが、組換えキメラタンパク質、遺伝子導入、シグナル伝達、リン酸化カスケードなどの研究が全盛の今日、これでは軽蔑の眼で見られるのが落ちだろう。こうしたあたりまえのような複雑さこそが、膜糖脂質の本質ともいえるのであるが、これが糖鎖部分の機能を調節している可能性が高まっている。人工的な表面を利用した糖脂質機能のアッセイでは、糖部分を本来の結合相手分子から切り離し、本来とは異なる (多かれ少なかれ) 生きていない担体に気安く移しているが、糖鎖とレセプターの働きを微調節できなくなくしている可能性がある。糖脂質糖鎖に対するレセプターの機能は、糖脂質り脂肪酸部分の影響によって、糖鎖の配列だけから予想したものよりも、少なくとも数倍は複雑になっていることが最近の研究で示唆されている。

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.911
Threshold uncertainty score0.808

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.002
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.021
GPT teacher head0.291
Teacher spread0.270 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations9
Published2000
Admission routes1
Has abstractyes

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