The role of microRNA-449 in Human Breast Cancer
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In 2010, an estimated 173 800 cases of cancer were diagnosed in Canada and 76 200 of these cases were expected to be fatal. Current treatment options are often very invasive, harmful, and ineffective. The purpose of this experiment was to mitigate tumour growth by manipulation of micro-RNA (mRNA) levels. mRNAs are small proteins, and levels of specific mRNAs are deregulated in cancer cells. In this experiment, levels of micro-RNA 449, which is deregulated in breast cancer cell lines, were returned to their baseline levels. Numerous tests were then conducted to test the viability of the resulting cells. Replicable experiments showed that the strength, motility and invasiveness of the breast cancer cells was greatly diminished after mRNA-449 levels returned to baseline levels. Furthermore, research indicated that 4 potential genes (CRIP2, XBP1, TAF4B, and SFXN2) can be manipulated in future experiments to further diminish the viability of the breast cancer tumours. En 2015, 25220 cas estimés de cancer du sein ont été diagnostiqués au Canada et 5060 de ces cas étaient prévus d’être fatales. Les options de traitement courantes sont souvent très envahissantes, nuisibles et inefficaces. L’objet de cette expérience était d’atténuer la croissance de la tumeur en manipulant les niveaux d’ARN-Micro. ARNm sont de petites molécules qui codent pour des protéines et en cellules de cancer, les niveaux de certains ARNms sont dérégulés. Les niveaux d’ARN-micro 449, qui sont dérégulés dans les lignées cellulaires de cancer du sein, ont été retournées à leurs niveaux de base dans cette expérience. La viabilité des cellules ainsi obtenues a été analysé par plusieurs tests. Les expériences reproductibles ont indiqué que la force, la mobilité et le caractère invasif des cellules de cancer du sein ont été diminués après que les niveaux d’ARN-micro 449 sont retournés à leurs niveaux de base. En outre, l’étude a révélé que quatre gènes potentiels (CRIP2, XBP1, TAF4B, et SFXN2) pourraient être manipulés à l’avenir pour réduire davantage la viabilité des tumeurs du cancer du sein.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it