Depletion of bromadiolone in tissues of hogs following oral exposure
Bibliographic record
Abstract
Objectives: To assess bromadiolone depletion in the edible tissues of swine and propose post-exposure withdrawal periods. Materials and methods: Two groups of barrows and two groups of gilts were given a single oral dose of bromadiolone: low dosage (LD, 0.05 mg/kg; n = 20; 10 males, 10 females) and high dose (HD, 0.5 mg/kg; n = 20; 10 males, 10 females). Coagulation parameters were assessed before and after administration. Animals were sacrificed at 1, 2, 3, 5, and 6 weeks (LD) and 1, 2, 3, 6, and 9 weeks (HD) post dosing. Loin muscle, skin-adherent fat, liver, feces, and blood were analyzed for bromadiolone using liquid chromatography-tandem mass spectrometry. Results: Partial thromboplastin times exceeded control values in the LD and HD groups 6 and 9 weeks post dosing, respectively. In the HD group, bromadiolone concentrations exceeded the limit of detection (LOD) at all time points in liver and skin-adherent fat and for up to 6 weeks in feces, muscle, and plasma. In the LD group, bromadiolone concentrations exceeded the LOD at all time points in liver and up to 3 weeks in fat, feces, and plasma. Estimated withdrawal periods for bromadiolone in liver were 83 and 176 weeks in the LD and HD groups, respectively, and 62 weeks in muscle in the HD group. Implication: Bromadiolone residues persist in tissues such that it is impractical to wait for the hog to eliminate the rodenticide to a concentration that is safe for entry into the human food chain.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".