Correlated Fluctuations of DNA between Nanofluidic Entropic Traps
Bibliographic record
Abstract
Here we explore thermally driven contour fluctuations within a single DNA chain partitioned between two embedded cavity reservoirs in a nanofluidic slit. Analysis of integrated cavity intensity suggests that contour is exchanged dynamically between the reservoirs via modes that resemble the symmetric and antisymmetric modes of a coupled harmonic oscillator. The relaxation time of the modes is measured as a function of cavity width and spacing. Langevin dynamics simulations reproduce our observations and motivate a free energy model with a blob-type hydrodynamic friction, developed and used to deduce how the measured relaxation times for the modes depend on device parameters. The relaxation time of the antisymmetric mode was found to be consistent with an excluded volume-based stiffness while the faster symmetric mode depends on additional entropic and elastic parameters.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".