Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Why is this work in the frame?
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
No Canadian affiliation. An affiliation-only frame — the usual design — would never have seen this work. It is one of the works that make the case for inverting the frame.
Machine scores (provisional)
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
- Teacher spread
- 0.318 · how far apart the two teachers sit on this one work
- Validation status
score_only:v0-immature-baseline· verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it
Abstract
OBJECTIVE: Structural brain imaging studies in obsessive-compulsive disorder (OCD) have produced inconsistent findings. This may be partially due to limited statistical power from relatively small samples and clinical heterogeneity related to variation in illness profile and developmental stage. To address these limitations, the authors conducted meta- and mega-analyses of data from OCD sites worldwide. METHOD: images from 1,830 OCD patients and 1,759 control subjects were analyzed, using coordinated and standardized processing, to identify subcortical brain volumes that differ between OCD patients and healthy subjects. The authors performed a meta-analysis on the mean of the left and right hemisphere measures of each subcortical structure, and they performed a mega-analysis by pooling these volumetric measurements from each site. The authors additionally examined potential modulating effects of clinical characteristics on morphological differences in OCD patients. RESULTS: The meta-analysis indicated that adult patients had significantly smaller hippocampal volumes (Cohen's d=-0.13; % difference=-2.80) and larger pallidum volumes (d=0.16; % difference=3.16) compared with adult controls. Both effects were stronger in medicated patients compared with controls (d=-0.29, % difference=-4.18, and d=0.29, % difference=4.38, respectively). Unmedicated pediatric patients had significantly larger thalamic volumes (d=0.38, % difference=3.08) compared with pediatric controls. None of these findings were mediated by sample characteristics, such as mean age or scanning field strength. The mega-analysis yielded similar results. CONCLUSIONS: The results indicate different patterns of subcortical abnormalities in pediatric and adult OCD patients. The pallidum and hippocampus seem to be of importance in adult OCD, whereas the thalamus seems to be key in pediatric OCD. These findings highlight the potential importance of neurodevelopmental alterations in OCD and suggest that further research on neuroplasticity in OCD may be useful.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
The record
- Venue
- American Journal of Psychiatry
- Topic
- Obsessive-Compulsive Spectrum Disorders
- Field
- Psychology
- Canadian institutions
- —
- Funders
- National Center for Advancing Translational SciencesNational Institute of Biomedical Imaging and BioengineeringNational Institute of Mental HealthInstituto de Salud Carlos IIIJapan Society for the Promotion of ScienceServierMedical Research CouncilCanadian Institutes of Health ResearchUniversiteit van AmsterdamCollege of Medicine, Seoul National UniversityCumming School of Medicine, University of CalgaryNational Institutes of HealthMinisterio de Ciencia e InnovaciónHamilton Health Sciences FoundationDepartment of Science and Technology, Ministry of Science and Technology, IndiaHospital for Sick ChildrenH. Lundbeck A/SUniversitat Autònoma de BarcelonaAgència de Gestió d'Ajuts Universitaris i de RecercaThe Wellcome Trust DBT India AllianceUniversity of Cape TownHumboldt-Universität zu BerlinMathison Centre for Mental Health Research and EducationUniversidade de São PauloEli Lilly and CompanyKoninklijke Nederlandse Akademie van WetenschappenCentro de Investigación Biomédica en Red de Salud MentalYale UniversityKarolinska InstitutetKunming Medical UniversityNational Institute of Mental Health and NeurosciencesSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungSeoul National UniversityUniversität ZürichMinistry of Education, Culture, Sports, Science and TechnologyBundesministerium für Bildung und ForschungEuropean Regional Development FundUniversitat de BarcelonaDeutsche ForschungsgemeinschaftTechnische Universität MünchenNederlandse Organisatie voor Wetenschappelijk OnderzoekUniversidade Federal do ABCNational Science FoundationDepartment of Biotechnology, Ministry of Science and Technology, IndiaCanadian Network for Mood and Anxiety TreatmentsUniversity of Southern CaliforniaWellcome TrustOntario Brain InstituteUniversity of CambridgeHamilton Health SciencesBristol-Myers SquibbMinistero della SaluteInternational OCD FoundationGlaxoSmithKline
- Keywords
- Meta-analysisMedicineSample size determinationBrain sizeInternal medicinePsychologyMagnetic resonance imagingRadiology
- Has abstract in OpenAlex
- yes