Inhibition of Myeloperoxidase by a Carbon Monoxide‐Releasing Molecule, CORM‐3
Bibliographic record
Abstract
Carbon monoxide (CO)‐releasing molecules (CORMs) have recently been shown to suppress inflammation by interfering with neutrophil function. However, the mechanisms are not completely understood. Neutrophilic myeloperoxidase (MPO) is known to induce tissue damage through: 1) the direct oxidation and/or 2) through the hypohalous acid‐dependent oxidation of targets. We hypothesized that CORM‐released CO inhibits MPO activity and thereby reduces neutrophil‐associated injury. In these studies, we used a water‐soluble, ruthenium‐based CORM (CORM‐3) that we synthesized and known to suppress inflammation. In vitro assays were used to study CO release under conditions relevant to inflammation. Further studies investigated CORM‐3's ability to inhibit total MPO activity as well as the activity of the peroxidation and halogenation components. Results indicate that CORM‐3‐released CO inhibited total MPO activity in a dose‐dependent manner. Furthermore, both the peroxidation and halogenation activities of MPO were inhibited by CORM‐3 in a dose‐dependent manner. On the contrary, control molecules; inactive CORM‐3 (a CORM lacking CO), or RuCl 3 were less effective. In summary, CORM‐3‐derived CO inhibits MPO activity and therefore may suppress neutrophil‐induced tissue damage. (HSFO NA6914 and LHRI IRF‐025‐09)
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".