The Long and the Short of Survival in Parkinsonism (P5.365)
Bibliographic record
Abstract
Objective: To identify autopsied PS groups of cases that have the longest and the shortest survival after onset. Background: Parkinson syndrome (PS) includes several degenerative disorders - most common being the idiopathic Parkinson’s disease (IPD). In 1950’s the mean life expectancy in IPD was 9.4 and in post encephalitic (PEP) PS cases was 25 years. Increased life expectancy in general population notwithstanding since the widespread use of levodopa in the 1970’s, the survival in IPD has increased. Methods: Movement Disorders Clinic Saskatchewan (MDCS) has operated continuously since 1968. The patients seen at MDCS are offered autopsy at no cost. Two groups of PS patients, those with > 20 years survival regardless of onset age and a group with onset before age 70 and < 10 year survival were identified. Results: Of total 537 autopsied cases, 392 had PS. Regardless of onset age, 60 PS cases survived 20 years or longer - all had onset by age 67 years. The majority (43 cases) had IPD, 2 had progressive supranuclear palsy (PSP) but none had multiple system atrophy (MSA). The longest surviving subgroup were four cases with unusual tauopathy, median onset age 28 years (13-53) and median survival 54 (25-61) years. None of that subgroup had history of encephalitis and all were levodopa responsive. Of 41 PS autopsied cases with onset before age 70 and survival less than 10 years - there were 16 PSP, 11 IPD and 7 MSA cases. Conclusions: PS cases with onset before age 60 have longer survival but that is significantly influenced by the underlying pathological process. Survival is the shortest in the MSA and the longest in rare form of tauopathy which is not consistent with the commonly known tauopathies.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".