OS 04-04 ANTIHYPERTENSIVE EFFECT OF MILK-DERIVATIVE TRIPEPTIDES. RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY ON THE EFFECTS OF GRANA PADANO CHEESE DOP IN HYPERTENSIVE PATIENTS.
Bibliographic record
Abstract
Objective: Present data refers to a randomized, double-blind, placebo-controlled, cross-over study in which 30 mild-moderate hypertensive patients, received a dietary integration with Grana Padano DOP cheese to evaluate blood pressure (BP) changes. Cow-milk fermentation induced by Lactobacillus helveticus produces peptides with sustained ACE inhibitory activity, mainly dues to 2 tripeptides (valyl-prolyl-proline and isoleucil-prolyl-proline) that have shown to lower blood pressure (BP) in experimental animals and in humans. Grana Padano DOP, an Italian semi-fat hard cheese, has shown a potent in-vitro ACE-inhibitory effect due its high concentration of such tripeptides. Design and Method: Thirty mild-moderate hypertensive patients presenting with BP values not on target (> 140 and /or > 90 mmHg) after their usual and stable (3 months at least) treatment were considered in the study. All patients received, in random fashion, a dietary integration with Grana Padano Cheese (30 g per day) and placebo (obtained with flavored bread mixed with fats and salts in concentrations equal to those of the cheese), in cross-over fashion. BP was evaluated at baseline and at the end of the active and placebo treatment (2 months each) by: -Office BP (OBP) and Automated Office BP using the BpTRU, (VSM MedTech Ltd, Vancouver, Canada), an automated oscillometric device that provides the average of multiple (6) blood pressure measurements. Results: The dietary integration with Grana Padano cheese resulted in a significant decrease in systolic and diastolic Office and Automated Office BP (BpTRU) mean values. The mean decrease (versus plaebo) was −6 mmHg for systolic and -5 mmHg for diastolic BP (Student's t test: p < 0.025 and p < 0.05 rispectively) Conclusions: Dietary integration with milk derivatives containing valyl-prolyl-proline and isoleucil-prolyl-proline (such as Grana Padano DOP cheese) may be helpful to reach BP target in mild -to-moderate hypertensive patients.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".