CE-49 Rheumatic and non-rheumatic autoimmune diseases in SLE offspring
Bibliographic record
Abstract
Background Autoimmune diseases (AID) have familial aggregation and frequently share a common genetic predisposition. Only few small uncontrolled studies have evaluated the risk of AID in SLE offspring, with inconsistent results. In a large population-based study, we aimed to determine if children born to mothers with SLE have an increased risk of rheumatic and non-rheumatic AID compared to children born to mothers without SLE. Materials and methods The “Offspring of SLE mothers Registry (OSLER)” includes all women who had ≥1 hospitalisation for delivery after SLE diagnosis, identified through Quebec’s universal healthcare databases (1989–2009). OSLER also includes a randomly selected control group of women, matched at least 4:1 for age and year of delivery, who did not have a diagnosis of SLE prior to or at the time of delivery. We identified children born live to SLE mothers and their matched controls, and ascertained rheumatic (i.e. juvenile idiopathic arthritis, SLE, systemic sclerosis, Sjögren’s disease, inflammatory myositis, systemic vasculitis) and non-rheumatic (i.e., type 1 diabetes, inflammatory bowel disease, psoriasis, celiac disease, autoimmune thyroid disease, myasthenia gravis, multiple sclerosis) AID based on ≥1 hospitalisation or ≥2 physician visits with a relevant diagnostic code, at least 2 months apart but within 24 months. The study interval spanned from birth to the first of the following: event of interest, age 18, death, or end of study. We performed multivariate analyses to adjust for maternal age, education, and ethnicity, as well as calendar year of birth and sex of the child. Results 509 women with SLE had 719 children, while 5824 matched controls had 8493 children. Mean follow-up was 9.1 (SD 5.8) years. Compared to controls, children born to mothers with SLE had similar records of rheumatic diagnoses [0.14% (95% CI: 0.01, 0.90) vs 0.19% (95% CI: 0.11, 0.32)]. However, there was a trend towards more non-rheumatic AID in offspring of mothers with SLE versus controls [1.11% (95% CI: 0.52, 2.27) vs 0.48% (95% CI: 0.35, 0.66)]. The most frequently observed non-rheumatic AID were Crohn’s disease (0.56% in SLE offspring, versus 0.19% in control children) and type 1 diabetes (0.42% in SLE offspring, versus 0.22% in control children). In multivariate analyses, children born to mother with SLE had a substantially increased risk of non-rheumatic AID compared to controls (OR 2.62, 95% CI: 1.10, 6.24), while results were inconclusive for the risk of rheumatic AID (OR 0.78, 95% CI: 0.10, 5.92). Conclusions Our novel data suggest that, compared to children from the general population, children born to women with SLE have an increased risk of non-rheumatic AID. Our effect estimate for the risk of rheumatic AID is inconclusive. Further study of these children, throughout late childhood, adolescence, and adulthood, would be additionally enlightening.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.012 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".