Preparation and Lectin Binding Property of Chitosan–Carbohydrate Conjugates
Bibliographic record
Abstract
Abstract Chitosan–sialic acid conjugates were prepared using p-formylphenyl α-sialoside by reductive N-alkylation. The degree of substitution (DS) of conjugates could be controlled from 0.06 to 0.53 by the amount of sialoside. With the use of p-isothiocyanatophenyl α-sialoside, chitosan–sialic acid conjugates were also prepared with excellent efficiency. Chitosan–melibiose conjugates having α-galactosyl epitope were also prepared by reductive N-alkylation. These conjugates were transformed into water-soluble forms by N-succinylation and their protein binding property was tested using wheat germ agglutinin (WGA) or Griffonia simplicifolia (GSI-B4) lectin. Strong immunodiffusion bands were observed in all of conjugates, thus demonstrating the specific binding of epitope in conjugate to each lectins.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".