Agranulocytosis Secondary to Ceftaroline Use: A Case Report and Review of the Literature
Bibliographic record
Abstract
Ceftaroline is a fifth generation cephalosporin with bactericidal activity against both gram-negative and gram-positive organisms, and is the only cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). A 23-year-old female with a history of frequent intravenous drug use was admitted to the medical intensive care unit with an MRSA infection resulting in bacterial meningitis, bacteremia and multifocal pneumonia. MRSA therapy was escalated during the admission to a combination of daptomycin and ceftaroline with subsequent clearance of her blood cultures. However, following the introduction of these medications, the patient developed agranulocytosis without parallel involvement of her other cell lines. This agranulocytosis resolved with discontinuation of ceftaroline. Clinicians must maintain vigilance with regard to patients’ neutrophil counts when prescribing treatment with ceftaroline for prolonged periods of time. J Hematol. 2016;5(3):103-105 doi: http://dx.doi.org/10.14740/jh281w
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.007 | 0.006 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.003 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".