Ferritin heavy polypeptide 1 mediates apoptosis-related gene expression of duck (<i>Anas platyrhynchos domesticus</i>)
Bibliographic record
Abstract
Duck hepatitis virus type 1 (DHV-1) infection of ducklings causes hepatitis and is associated with high morbidity and mortality. Virus infection may induce apoptosis and inhibit proliferation. In humans, ferritin heavy polypeptide 1 (FTH1) has been reported to affect the development of hepatitis and inhibit apoptosis. However, the effect of duck FTH1 (duFTH1) on apoptosis in DHV-1 infected ducklings has not been investigated. Therefore, we measured duFHT1 expression in tissues of DHV-1 infected ducklings and characterized the functional effects of ectopic overexpression and endogenous downregulation of FTH1 in duck embryo fibroblasts (DEF) to elucidate possible mechanisms involved. In the present study, the expression of duFTH1 was decreased in liver and spleen after DHV-1 infection. The effects of altered FTH1 expression on expression of pro- and anti-apoptotic genes were evaluated by qPCR arrays. Decreased expressions of Caspase-3 and Caspase-8 were observed in FTH1-overexpressing DEF cells, while decreased expression of Bcl-2 was detected in FTH1 knocked down DEF cells. Our findings suggest that the regulation of FTH1 expression indirectly mediated the expression of apoptosis-related genes; the protective effect of FTH1 was associated with the inhibition of apoptosis in DEF.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".