P4‐318: Apoe Genotype, Serum Plasmalogens, Cognition, and Mortality: a Pre‐Mortem Analysis in Elderly Persons
Bibliographic record
Abstract
Apolipoprotein E (ApoE) genotype and serum plasmalogen (PlsEtn) levels have previously been associated with cognitive status in independent studies. APOE genotype and cognition are also associated with mortality. The association between ApoE genotype, pre-mortem serum PlsEtn and either cognition, presence of dementia, or a diagnosis of mild cognitive impairment (MCI) or Alzheimer’s Disease (AD) with mortality in elderly persons was investigated. Serum PlsEtn, ApoE genotype, cognition, presence of dementia and a diagnosis of no cognitive impairment (NCI), MCI, or AD were determined in 1743 living persons aged 58-104 (85.2+/-7.4, Rush University Religious Orders Study and Memory and Aging Project). Of these persons, 847 have since deceased. The average time to death from the collection of cognition and serum PlsEtn levels was 1.6+/-1.6 years. A quantitative PlsEtn Biosynthesis Value (PBV) was generated for each person by combining the relative serum levels of three key PlsEtn species. Odds ratios (OR) of continuous variables expressed per standard deviation (SD). All models adjusted for age, education, and gender. Higher cognition and higher PBV were independently associated with lower mortality (OR=0.511, p<0.001; OR=0.475, p<0.001, respectively). The presence of dementia and PBV were independently associated with mortality (OR=2.98, p<0.001; OR=0.435, p<0.001, respectively). PBV and a diagnosis of either MCI or AD (relative to NCI) were associated with mortality ((OR=0.450, p<0.001; OR=2.22, p<0.001; OR=4.40, p<0.001, respectively). Relative to APOE ε3ε3, neither the APOE ε2ε3 nor APOE ε3ε4/ε4ε4 genotype was associated with mortality after adjusting for PBV and either cognition, dementia or diagnosis of MCI or AD. In elderly persons, higher PBV and cognition are independently associated with a lower odds of mortality and the presence of dementia or a diagnosis of MCI or AD are independently associated with a higher odds of mortality. APOE genotype was not associated with mortality after correcting for cognitive status, dementia, or diagnosis.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".