Situating the default-mode network along a principal gradient of macroscale cortical organization
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Abstract
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.
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The record
- Venue
- Proceedings of the National Academy of Sciences
- Topic
- Functional Brain Connectivity Studies
- Field
- Neuroscience
- Canadian institutions
- McGill UniversityMontreal Neurological Institute and Hospital
- Funders
- National Institute of Biomedical Imaging and BioengineeringNational Institute of Neurological Disorders and StrokeNational Institute of Mental HealthEuropean Research CouncilNational Institutes of HealthGovernment of CanadaCanadian Institutes of Health ResearchMcDonnell Center for Systems NeuroscienceBiotechnology and Biological Sciences Research CouncilJohn Templeton Foundation
- Keywords
- Default mode networkPrincipal (computer security)Mode (computer interface)Functional connectivityNeuroscienceComputer sciencePsychologyComputer securityHuman–computer interaction
- Has abstract in OpenAlex
- yes