P2‐332: Cognitive Changes, Androgens' Level and Apolipoprotein E Polymorphism in Postmenopausal Women
Bibliographic record
Abstract
Receptors for estrogens, androgens, and progesterone are widely distributed in the brain and expressed within discrete neural populations, and hormones and especially hormonal changes may influence brain function through other mechanisms. Changes in the hormonal balance after menopause have the potential to affect cognitive function and mood as well as physiological processes linked to cognitive aging and late-life disorders, such as Alzheimer’s disease. A number of studies have examined those and most have focused on 17β-estradiol permanent reduced after menopause. Findings related to cognition in this setting are however inconsistent. The focus of this study was to assess cognitive functions in relation to androgens and specifically testosterone and dehydroepiandrosterone in postmenopausal women as well as correlation between cognitive functions and these two androgens with apolipoprotein E polymorphism. The group of 402 women was recruited to the study (minimum two years after the last menstruation, FSH more than 30 U/ml and no dementia signs on Montreal Cognitive Assessment). Computerized battery of Central Nervous System Vital Signs test was used to diagnostic cognitive functions. APOE genotype was performed by multiplex PCR. TTE and DHEA in the blood serum we assessed for further statistical correlations analysis. In the group of postmenopausal women higher testosterone concentration corresponded with the lower scores for NCI, memory and psychomotor speed. Presence of at least one ε4 APOE allele potentiated testosterone’s negative influence on cognitive functions. As for DHEA high level of normal range of levels was related to better results for memory both verbal and visual in the examined women after menopause. APOE polymorphism did not modify the relationship between DHEA concentration and scores for cognitive functions. Hormonal balance variations after menopause may influence brain processes concerned with cognition especially memory and psychomotor speed. Effects observed may be related to androgens influence on higher cortical functions in the changed hormonal dynamics of postmenopausal period.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".