P1‐243: Chronic Inflammation and APOE Polymorphism: Modyfiers of Cognitive Functioning in Postmenopausal Women
Bibliographic record
Abstract
The initiation and development of both cardiovascular as well as cognitive disorders is believed to be partly linked to inflammation. Specifically, C-reactive protein (CRP), a marker of chronic inflammation, has been associated with numerous clinical conditions, including cognitive decline. Speculatively, CRP may indirectly lead to cognitive impairment via promoting vascular disease. In another hypothesis CRP is produced as a result of the inflammatory process linked to a myriads of lifestyle factors (e.g. obesity, smoking, poor diet, lack of activity etc.) and is therefore simply a by-product linked to adverse lifestyle. Similarly cardiovascular as well as cognitive impairment are at increased risk in the presence of APOE 4 allele. Both inflammatory processes as well as APOE polymorphism independently seemed to play a role in often expeditiously progressive post-menopausal cognitive dysfunction. It seems interesting to explore the interplay of both factors in the etiology of post-menopausal cognitive impairment. In this study relationship between levels of cognitive functions in relation to CRP level in the context of APOE polymorphisms were studied in the cohort of post-menopausal women. The group of 402 women was recruited to the study. The inclusion criteria were: minimum two years after the last menstruation, FSH concentration 30 U/ml and no dementia signs on Montreal Cognitive Assessment (MoCA). Computerized battery of Central Nervous System Vital Signs (CNS VS) test was used to diagnostic cognitive functions. APOE genotype was performed by multiplex PCR. The blood plasma was determined C-reactive protein (CRP). Statistical analysis was performed using STATISTICA software. The level of cognitive functions in postmenopausal women depends on apolipoprotein E gene polymorphism and the concentration of C-reactive protein (CRP). Women homozygotous for APOE ε4/ε4 scored the lowest on cognitive testing and presented with higher CRP levels. Apolipoprotein E gene polymorphism may modify the relationship between CRP concentration and cognitive functions in postmenopausal women.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".