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36th International Symposium on Intensive Care and Emergency Medicine
R. M. Bateman, Michael D. Sharpe, Justin E. Jagger, Chiara Ellis, Jordi Solé‐Violán, M. López Rodríguez, Estefanía Herrera‐Ramos, JA Ruiz-Hernández, Luis Borderías, Juan Pablo Horcajada, N. González-Quevedo, Olga Rajas, Ma Luisa Briones, Felipe Rodrı́guez de Castro, Claudio Gallego, Figen Esen, Perihan Ergin Özcan, Evren Şentürk, Canan Uğur Yılmaz, Nurcan Orhan, Nadir Arıcan, M. Kaya, Melike Küçükerden, Murat Giriş, Uğur Akcan, Sema Bilgiç Gazioğlu, Eray Tüzün, Reut Riff, Oshri Naamani, Amos Douvdevani, Ryosuke Takegawa, Hisao Yoshida, Tomoya Hirose, Naoki Yamamoto, Hideharu Hagiya, Masahiro Ojima, Osamu Tasaki, Kazunori Tomono, Toshio Kubo, S Suda, Hiroshi Ogura, Hiroki Takahashi, J. Kang, Youhei Nakamura, Takashi Kojima, Yoshito Izutani, Takuya Ueno, Satoshi Ono, Tadatsugu Taniguchi, M. O, C. Dinter, J. Lotz, Beth Eilers, Christian Wißmann, Rex S. Lott, Marc Meili, Philipp Schüetz, Hassan Hawa, M. Aburageila, Nawal Salahuddin, Vasiliki Chantziara, Sophia Georgiou, Angeliki M. Tsimogianni, Panagiotis Alexandropoulos, A. Vassi, F. Lagiou, M. Valta, Georgia Micha, E. Chinou, G. Michaloudis, A. Kodaira, Hitoshi Imaizumi, María Victoria de la Torre-Prados, A García-de la Torre, Alfredo Enguix-Armada, A Puerto-Morlán, V. Perez-Valero, Ángel García-Alcántara, N. Bolton, J. Dudziak, Samantha Bonney, Ascanio Tridente, Patrick Née, Gerry A. F. Nicolaes, Maryse A. Wiewel, MJ Schultz, K. Wildhagen, Janneke Horn, Roy Schrijver, Chris Reutelingsperger, Suresh Pillai, Graham Mills, R. Aubrey, K. Morris, P. Williams, P. Evans, Étienne Gayat, Julian P. Struck, Alain Cariou, Nicolas Deye, Bertrand Guidet, S. Jabert, Jean‐Marie Launay, M Legrand, Marc Léone, Matthieu Resche‐Rigon, Éric Vicaut, Antoine Vieillard‐Baron, Amel Mebazâa, R. Arnold, Müge Capan, Adam Linder, Per Åkesson, Marius Nicolae Popescu, Charles L. Sprung, Ricardo Morales, G Munteanu, Efrat Orenbuch‐Harroch, Phillip D. Levin, Harvey L. Kasdan, Austin Reiter, T. Volker, Y. Himmel, Yves Cohen, Julien Meissonnier, Louis Girard, Fabien Rebeaud, I. F. Herrmann, Benjamin Delwarde, Estelle Peronnet, Enrico Cerrato, Fabienne Venet, Alain Lepape, Thomas Rimmelé, Guillaume Monneret, Julien Textoris, Beloborodova Nv, V. Moroz, A. А. Osipov, A. Yu. Bedova, Y. Sarshor, Aliсa K. Pautova, A. E. Sergeev, Ekaterina Chernevskaya, Jonas Odermatt, Rebekka Bolliger, Lara Hersberger, M. Ottiger, Mirjam Christ‐Crain, Narendra Kumar Sharma, A. K. Tashima, Milena Karina Coló Brunialti, Flávia Ribeiro Machado, M. Assuncao, Otelo Rigato, Reinaldo Salomão, Sara Cajander, Gail E. Rasmussen, Elisabet Tina, Bo Söderquist, Jeremy Kallman, Kristoffer Strålin, Audun Lange, Jonas Sundén‐Cullberg, Anders Magnuson, Olof Hultgren, P. Evans, Paul Williams, P. Van der Geest, Mostafa Mohseni, Jo Linssen, Rogier de Jonge, Servet Duran, Johan Groeneveld, R. Miller, Bert K. Lopansri, Leo McHugh, A. Seldon, J. P. Burke, J. Johnston, Rosie Reece-Anthony, A. Bond, A. Molokhia, Christopher McGrath, E. Nsutebu, Peter Bank Pedersen, Daniel Pilsgaard Henriksen, Søren Mikkelsen, Annmarie Touborg Lassen, Cristian Cobilinschi, Z. Ghiorghiu, Matthew B.A. Harmon, Lonneke A. van Vught, Brendon P. Scicluna, Arie J. Hoogendijk, A. H. Zwinderman, Olaf L. Cremer, Marc J. M. Bonten, Tom van der Poll, Gülay Eren, Y. Tekdos, Mustafa Hakan Dogan, Özlem Acicbe, Ergün Barış Kaya, Oya Hergünsel, Ghassan Al Ghamdi, Lolowa Alswaidan, Saleh Alharbi, Fatimah Freih Alenezi, Yaseen M. Arabi, J. D. Heaton, Adam Boyce, Lea Nolan, A. Dukoff-Gordon, A. Dean, T. Mann Ben Yehudah, C. Fleischmann, C. Haas, Onnicha Suntornlohanakul, Bodin Khwannimit, F. Breckenridge, Alex Puxty, Petr Szturz, P. Folwarzcny, Jan Švancara, Roman Kula, P. Sevcik, Luca Caneva, Alberto Casazza, E. Bellazzi, Serena Marra, Laura Pagani, M. Lo Vetere, R. Vanzino, D. Ciprandi, R. Preda, R. Boschi, L Carnevale, Victor Lopez, M. Aguilar Arzapalo, L. Barradas, J. Gongora, M. Cetina, Barbara Adamik, D Jakubczyk, Andrzej Kübler, Anthony J. Radford, T. Lee, Joel Singer, John H. Boyd, David Fineberg, Michael Williams, James A. Russell, Ecaterina Scărlătescu, Dana Tomescu, Gabriela Droc, Sorin Ștefan Aramă, María José Conejero Müller, Marleen Straat, Sacha Zeerleder, Cathérine Fuchs, Christian Scheer, S. W. Wauschkuhn, Marcus Vollmer, Konrad Meissner, Simone Kühn, Klaus Hahnenkamp, S. Rehberg, Matthias Gründling, Shigeto Hamaguchi, Takeshi Shimazu, Kazunori Tomono, E. Gómez-Sánchez, María Heredia‐Rodríguez, E. Álvarez-Fuente, Mario Lorenzo‐López, M. Fernandez Aragon, P. Liu-Zhu, A. Hernández-Lozano, M. T. Peláez-Jareño, Eduardo Tamayo, Daniel Thomas‐Rüddel, V. Adora, A Kar, Apu Chakraborty, Sayak Roy, Arun Bandyopadhyay, Manoja Kumar Das, Gal Ben‐Yehudah, Mohammad Salim, Neelja Kumar, T. Burger, Paul Lephart, E. Toth-martin, C. Valencia, Naïma Hammami, Stijn Blot, Jean‐Louis Vincent, M.-L. Lambert, Jana Brunke, T. Riemann, Ingolf Roschke, Radu Alexandru Macovei, S. Nimitvilai, Kavita Jintanapramote, S. Jarupongprapa, Dalia Adukauskienė, Dovilė Valančienė, Gauruv Bose, Vasileios Lostarakos, Bryan Carr, S. Khedher, A. Maaoui, A. Ezzamouri, Marwa Rashad Salem, Jenny Chen, Duncan R Cranendonk, Michael Day, G. Penrice, Koyel Roy, Paul L. Robertson, Gauri Godbole, Brad Jones, M Booth, Lindsay Donaldson, Yasumasa Kawano, Hiroyasu Ishikura, H. Al-Dorzi, Marwan Obaid Al-Mutairi, B. Alhamadi, A. Crizaldo Toledo, R. Khan, Basel Al Raiy, Hans van Oers, A. Harts, Ellen Nieuwkoop, Piet Vos, Y. Boussarsar, F. Boutouta, Salma Kamoun, I. Mezghani, S. Koubaji, A. Souissi, Anis Riahi, Mhamed Sami Mebazaa, E Giamarellos-Bourboulis, Nikolaos Tziolos, Christina Routsi, Chrisostomos Katsenos, Iraklis Tsangaris, Ioannis Pneumatikos, G. Vlachogiannis, Vasiliki Theodorou, Athanasios Prekates, Elli Antypa, V. Koulouras, N. Kapravelos, Charalambos Gogos, E Antoniadou, K. Mandragos, Apostolos Armaganidis, A. R. Robles Caballero, Belén Civantos, Juan Carlos Figueira, Jessica Lopez, André Silva‐Pinto, Fátima Ceia, António Sarmento, Luís Santos, Ghaleb A. Almekhlafi, Yasser Sakr, Salim Baharoon, A. S. Aldawood, Amal Matroud, John Alchin, Sameera Al Johani, Hanan H. Balkhy, Sami Alsolamy, Sami Yousif, B. O. Alotabi, Abdulmohsen Alsaawi, Jocelyn Y. Ang, M. D. Curran, David Enoch, V. Navapurkar, Andrew Conway Morris, R. Sharvill, Jonathan W. Astin, Jina Patel, Carsten Krüger, J. O’Neal, H. Rhodes, J. Jancik, Bruno François, Pierre-François Laterre, Philippe Eggimann, A. Torres, Pierre‐François Dequin, Gianluigi Li Bassi, Majdi Ben Romdhane, Z. Douira, M. Bousselmi, A. Vakalos, V. Avramidis, Thomas Craven, G. Wojcik, Kallirroi Kefala, J. McCoubrey, J. Reilly, R. Paterson, Donald Inverarity, Ian F. Laurenson, Timothy Walsh, Silvia Mongodi, B. Bouhemad, Anita Orlando, Andréa Stella, Gabriele Via, Giorgio Antonio Iotti, Antonio Braschi, Francesco Mojoli, Beliz Bilgili, Umut Sabri Kasapoğlu, İsmet Sayan, Melek Süzer Aslan, S. Yalçin, İsmail Cinel, Helen Ellis, Donna Miller, A. Temple, C. E. Luyt, Mervyn Singer, Yasser Sadek Nassar, Ahlem Trifi, Sami Abdellatif, Frank Daly, Rochdi Nasri, Salah Ben Lakhal, F. Gul, A. Kuzovlev, А. К. Шабанов, S. G. Polovnikov, N. Kadrichu, Tran Dang, K Corkery, P. Challoner, Eva de los Ángeles Miralles Aguilera, Chiara Chiurazzi, Chiara Travierso, Ana Motos, Lucila María Pérez Fernández, Rosanel Amaro, Tarek Senussi, Francesco Idone, Joaquim Bobí, Montserrat Rigol, C. J. Hodiamont, J. M. Janssen, Catherine S. C. Bouman, Ron A. A. Mathôt, Menno D. de Jong, Reinier M. van Hest, Liz Payne, Gilles L. Fraser, Bianca Tudor, Matthias Lahner, Georg A. Roth, C. G. Krenn, Haleh Talaie, P. Jault, J. Gabard, Thomas Leclerc, Serge Jennes, Yok‐Ai Que, A. Rousseau, François Ravat, Abdullatif Yasir H Eissa, Tarek Aldabbagh, F. Paramba, Nishan K Purayil, Vamanjore A Naushad, Osama Hashim Mohammad, V. Negi, P. Prarthana Chandra, A. Kleinsasser, M. R. Witrz, J. F. Buchner-Doeven, A. M. Tuip-de Boer, J. Carel Goslings, M. Van Hezel, Alexandra Crispim Boing, Rykel van Bruggen, N. P. Juffermans, Dimitra Markopoulou, Kyriaki Venetsanou, Vasileios Kaldis, D. Koutete, D. Chroni, Ioannis Alamanos, Lionel Koch, E. Walter, Kenichiro Maekawa, Mineji Hayakawa, Shigeki Kushimoto, Atsushi Shiraishi, H. Kato, Junichi Sasaki, T. Matauoka, Toshifumi Uejima, Naoto Morimura, Akira Hagiwara, Masahide Takeda, О. Тарабрин, S. Shcherbakow, D. Gavrychenko, G. Mazurenko, Вероника Алексеевна Иванова, O. Chystikov, Collin Plourde, Justine Lessard, Jean‐Marc Chauny, Rita D’Aoust, L. Kropman, L. In het Panhuis, J. Konings, Dana Huskens, Evelien Schurgers, Mark Roest, Bas de Laat, Marcus D. Lancé, Miroslav Durila, Marta Astraverkhava, Ivan Budnik, Elizabeth Shenkman, H Hayami, Y. Koide, Takashi Goto, Rehana Iqbal, Yasir Alhamdi, Neethu Venugopal, Simon T. Abrams, C. Downey, Cheng‐Hong Toh, Ingeborg Welters, V. B. Bombay, R. D. Daoust, Martin Marquis, J. P. Paquet, K. Siemens, Dilanee P. Sangaran, B. J. Hunt, Andrew Durward, Andrew Nyman, I. A. Murdoch, SM Tibby, Fotini Ampatzidou, E. Dalampini, M. Nastou, E. Vasilarou, V. Kalaizi, H. Chatzikostenoglou, George Drossos, Alberto Fogagnolo, T Fiore, Adam Schiavi, V. Fontana, Fabio Silvio Taccone, Carlo Alberto Volta, Elpis Chochliourou, Eleni Volakli, A. Violaki, G. Evlavis, R. Mothukuri, Ceri Battle, K. Guy, Julian Wijesuriya, Sean Keogh, Annemarie B Docherty, R O’Donnell, Susan J Brunskill, Marialena Trivella, Carolyn Dorée, Line Marie Holst, M. Parker, Markil Gregersen, Juliano Pinheiro de Almeida, Simon Stanworth, Sarka Moravcova, Jenny Mansell, A. Rogers, R. A. Smith, Colin Hamilton-Davies, Amr Salah Omar, Mahmoud Allam, O. Bilala, Ali Kindawi, HA Ewila, Angelakis Malamas, G. Ferreira, José Guilherme Mendes Pereira Caldas, J Fukushima, E Osawa, E. Arita, Suely Pereira Zeferino, Jaquelline Maria Jardim, F. Gaioto, Luís Roberto Palma Dallan, Fábio Biscegli Jatene, Roberto Kalil Filho, Filomena Regina Barbosa Gomes Galas, Ludhmila Abrahão Hajjar, Chieko Mitaka, Tetsu Ohnuma, T. Murayama, Fumio Kunimoto, Maki Nagashima, Tatsuro Takei, Makoto Tomita, Karim M. Mahmoud, Samy Hanoura, Suraj Sudarsanan, Praveen Sivadasan, H. Othamn, Yasser Shouman, Rajvir Singh, A. Al Khulaifi, Irina A. Mandel, S. Mikheev, I. V. Suhodolo, В В Киселев, Yuri Svirko, Yu. K. Podoksenov, Stephen A. Jenkins, Ruth Griffin, M. S. Tovar Doncel, César Aldecoa, Can İnce, Asma A. Taha, Ahmed Shafie, Magdi Mohammad Mostafa, Nauroz Syed, H. Hon, E. Colombaroli, G. Castellano, Marilyn Hravnak, L. C. Chen, Artur Dubrawski, Gilles Clermont, Michael R. Pinsky, Sergio González, P. Jimenez, Ana Loza, A. Lesmes, F. Muñoz Lucena, C. Cruz De Leon, M. Bastide, Jack Richecoeur, Éric Frenoy, C. Lemaire, Bertrand Sauneuf, Fabienne Tamion, Saad Nseir, Damien du Cheyron, Hervé Dupont, Julien Maizel, M Shaban, Rachel P. Kolko, Moh’d A. Sharshir, Ali Hassan Alhussain, Loay Kontar, Franck Brazier, M. Joris, Thierry Soupison, M. Slama, J. Wagner, A. Kørner, Mathias Kubik, Stefan Kluge, Danielle Reuter, Bernd Saugel, Francesca Righetti, Thao Mai Phuong Tran, David De Bels, Antonella Cudia, Mihai Strachinaru, P. Ghottignies, Jacques Devriendt, Charalampos Pierrakos, Ó. Martínez González, Rafael Blancas, Juán Luján, D. Ballesteros, Chanelle Diaz, A. Núñez, C. Martín Parra, Blanca López Matamala, M. Alonso Fernández, Manik Chana, Wolfgang Huber, Maximilian Eckmann, Felicia Elkmann, Andreas Gruber, Isabelle Klein, Roland M. Schmid, Tobias Lahmer, Peter Möller, Sören Söndergaard, Stephan M. Jakob, Jarmo Takala, Douglas Berger, Davide Bastoni, L. Toscani, Luca Pigozzi, Andrew Rhodes, Maurizio Cecconi, C. Ostrowska, Abbas As, Johannes Mellinghoff, Claire Ryan, D. Dawson, Maria Cronhjort, Olof Wall, Eric Nyberg, Rui Zeng, Christer Svensén, Johan Mårtensson, Eva Joelsson‐Alm, Nicola Parenti, Carlo Palazzi, L. A. Amidei, Felice Borrelli, S. C. Campanale, F. T. Tagliazucchi, G. S. Sedoni, Davide Lucchesi, E Carella, Anita Luciani, Maja Mačković, Nikolina Marić, Marija Bakula, H. Aya, RM Grounds, Nick Fletcher, P. Zhang, Mehdi Mezidi, Jonathan Charbit, M. Ould-Chikh, Pauline Deras, Caroline Maury, Omar Martínez, Xavier Capdevila, Peter C. Hou, WT Linde-Zwirble, I. D. Douglas, Nancy S. Shapiro, Y. Ben Aicha, Bedis Jeribi, Caroline R M Pereira, Rui Antunes, M. Crivits, Maarten Raes, Eric A. J. Hoste, В. А. Багин, В. А. Руднов, A. Savitsky, M. Astafyeva, Igor Korobko, V. I. Vein, Tim Kampmeier, Philip‐Helge Arnemann, Michael Heßler, Anna Wald, K. Bockbreder, Andrea Morelli, Hugo Van Aken, Christian Ertmer, Rinaldo Bellomo, Diane Mackle, Alex Psirides, Paul J. Young, H. A. Venkatesh, S. Ramachandran, Abhijit Basu, Harikrishnan V Nair, Sarah A. Egan, J Bates, C. P. Lee, Xue-Wei Lin, Casey Choong, Kar Mun Eu, W. Y. Sim, Kuan Sen Tee, Jessica Pau, John Abisheganaden, K. Maas, Hilde de Geus, E. Lafuente, T. E. Doris, Diane Monkhouse, Tim Shipley, Stephen Kardasz, Ivis Gonzalez, Susanne Stads, A. J. Groeneveld, I. Elsayed, Nick Ward, Ajay Raithatha, A. Steuber, C. Pelletier, Stefan Schröder, E. Michael, Torsten Slowinski, Detlef Kindgen‐Milles, S. Ghabina, Franco Turani, Antonio Belli, Silvia Busatti, G. Barettin, F. Candidi, F. Gargano, R Barchetta, M Falco, Oktay Demirkıran, M. E. Kosuk, Süha Bozbay, Viktoria Weber, Jens Hartmann, Stephan Harm, Ingrid Linsberger, T. Eichhorn, G. Valicek, Georg Miestinger, Christoph Hoermann, Stefano Faenza, Donna Ricci, Elizabeth Mancini, Carley N. Gemelli, Aurora Cuoghi, Silvia Magnani, Marta Luisa Ciofi degli Atti, Tommaso Laddomada, Andrea Doronzio, B Balicco, M. C. Gruda, Patricia O’Sullivan, Viorela Dan, T. Guliashvili, A. Scheirer, T. D. Golobish, V. J. Capponi, PK Chan, Klaus Kogelmann, Matthias Drüner, Dominik Jarczak, Alain Belli, S. M. Martni, Virginia Cotticelli, F. Mounajergi, Shinichi Morimoto, Islam Hussain, Amina Nadeem, Khaled Ghorab, Khalid Maghrabi, Stephan Kloesel, C. Goldfuss, A. S. Stieglitz, L. Krstevska, Gerd Albuszies, G Jimmy, Junichi Izawa, Taku Iwami, S. Uchino, Masanori Takinami, Τakeshi Kitamura, Takashi Kawamura, J. Powell-Tuck, Siobhan Crichton, Mário Raimundo, Luigi Camporota, D. Wyncoll, M. Ostermann, Anisa Hana, H. R. De Geus, Müge Aydoğdu, Nazlıhan Boyacı Dündar, Seher Yüksel, A. B. Cayci Sivri, José Martín Meza-Márquez, J. Nava-López, Raúl Carrillo-Esper, Alain Dardashti, Anders Grubb, Marnie M. Wetzstein, B. De Cagny, Theo Peters, H. Njimi, P. Pickkers, Manprit Waraich, James F. Doyle, Theophilus Samuels, Lui G. Forni, Nishita Desai, Rachel Baumber, Peter W. Gunning, A Sell, S. C. Lin, Harold Torrence, Michael J. O’Dwyer, Christopher J. Kirwan, T. Kim, Russ Hewson, Rupert M. Pearse, M. Maksoud, John R. Prowle, Osman Uzundere, Dilek Memiş, M. Ýnal, Ahmet Gültekin, Nuray Turan, MA Aydın, Halil Başar, İrfan Şencan, A. Kapuağası, Mehmet Öztürk, Z. Uzundurukan, Ayşe Özcan Küçük, Çetin Kaymak, В. А. Артеменко, A. Budnyuk, Richard Pugh, Sunil Bhandari, Tommaso Mauri, Cecilia Turrini, Thomas Länger, Paolo Taccone, C. Marenghi, Luciano Gattinoni, Lisa Sweeney, Andrew O’Sullivan, Paula Kelly, E. Mukeria, Ronan MacLoughlin, Michael A. Pfeffer, J Thomas, G. B. Bregman, G. K. Karp, E. K. Kishinevsky, Dekel Stavi, Nimrod Adi, T. Poropat, Rihard Knafelj, E. Llopart, Montserrat Batlle, Candelaria de Haro, Jaume Mesquida, Antonio Artigas, D. Pavlović, Lars Lewerentz, Alexander Spassov, Romy Schneider, Steven Smet, Sylvie De Raedt, E. Derom, Pieter Depuydt, Sandra Oeyen, Dominique Benoît, André Luiz Nunes Gobatto, Bruno Adler Maccagnan Pinheiro Besen, Paulo Fernando Guimarães Morando Marzocchi Tierno, Lívia Maria Garcia Melro, Pedro Vitale Mendes, Filipe Matheus Cadamuro, M. Park, Luíz Marcelo Sá Malbouisson, Anamaria J. Robles, S. Yus, Angela S. García, A. Oglinda, G. Ciobanu, C. Oglinda, L. Schirca, T. Sertinean, V. Lupu, Michael Wolny, Anna Pagano, G. Visone, Lavinia Saldamarco, Thiago Luiz Russo, G. Porta, Fiorella Paladino, Chaim M. Bell, J. Liu, Julian deBacker, C. Lee, E. Tamberg, V Campbell, S. Mehta, Yeşim S. Kara, F. Yýldýrým, Avşar Zerman, Z. Güllü, B. Basarýk Aydogan, Ü. Gaygýsýz, Kamil Gönderen, G. Arýk, Melda Türkoğlu, Gülbin Aygencel, Zekeriya Ülger, Z. Isýkdogan, Özlem Özdedeoğlu, Melike Badoğlu, Napplika Kongpolprom, Chanchai Sittipunt, Arif Onur Eden, Y. Kokhanovsky, SYLVIANNE BURSZTEIN DE MYTTENAERE, Reuven Pizov, Luke Neilans, Neil R. MacIntyre, Misty A. Radosevich, Brendan T. Wanta, T. Meyer, Nathan J. Smischney, Deborah Brown, Daniel A. Diedrich, A. Oveta Fuller, P. McLindon, K. Sim, M. Shoaeir, K. Noeam, Amr A. Mahrous, Ramprasad Matsa, Asma Amir Ali, C. Dridi, Haddad Fs, Ángel Augusto to Pérez-Calatayud, Adriana Denise Zepeda-Mendoza, M. Diaz-Carrillo, Emilio Arch-Tirado, S. Carbognin, L. Pelacani, Federico Zannoni, Alicia Agnoli, G. Gagliardi, R. Cho, Anne Adams, Scott Lunos, S. Ambur, R Shapiro, Matthew E. Prekker, M. Thijssen, L. Janssen, Norbert A. Foudraine, J. Freeman, Ed George, D. Eversole, Stefano Muttini, R. Bigi, Giovanni Villani, Nicolò Patroniti, Christopher Voscopoulos, Annika Waldmann, S. Böhm, Wolfram Windisch, C. Karagiannidis, Per Persson, S. Lundin, O. Stenqvist, C. S. Serra, Mario Masarone, L. R. Rinaldi, Annalisa Amelia, M. F. Fascione, L. A. Adinolfi, Elisa Ruggiero, F. Asota, Kevin O’Rourke, Sameer Ranjan, P. Morgan, L. O’Neill, Laveena Munshi, Lisa Burry, E. Fan, Shanti Mehta, Stephanie Poo, K Mahendran, Jo-anne Fowles, Caroline Gerrard, Alain Vuylsteke, Robert Loveridge, Charles Gilbert Chaddock, S. Patel, Vivek Kakar, C. Willars, T. Hurst, C. Park, Tony Best, André Vercueil, Georg Auzinger, Andrew Borgman, Alastair Proudfoot, Edgars Grins, K. E. Emiley, Joan Schuitema, Stephen Fitch, G. Marco, Jamie Sturgill, Michael G. Dickinson, M. Strueber, A. Khaghani, P. Wilton, S. M. Jovinge, Christopher Sampson, S. Harris-Fox, Matthew E. Cove, Lien Hong Vu, Ayan Sen, William J. Federspiel, John A. Kellum, Cristina Torre, Jordi Riera, Sarah Stewart de Ramirez, Bárbara Borgatta, Leonel Lagunes, Jordi Rello, Arkady Goloubev, S. Nenchuk, V. Karavana, C. Glynos, Andreas Asimakos, Karalyn Pappas, Charikleia S. Vrettou, M. Magkou, Eleni Ischaki, Georgios T. Stathopoulos, S. Zakynthinos, Iryna Kozhevnikova, Francesca Dalla Corte, Salvatore Grasso, Paolo Casolari, Gaetano Caramori, T. Andrianjafiarinoa, T.A.V. Randriamandrato, Tovohery Andriambelo Rajaonera, S. El-Dash, Eduardo Leite Vieira Costa, Mauro R. Tucci, François Leleu, G. Bacari-Risal, Marcelo B. P. Amato, Sangita Dash, Amanda Fischer, S. Squire, M. Boichat, Hiroshi Honzawa, T. Adati, Shinichiro Suzaki, Masayasu Horibe, Mika Sasaki, Masamitsu Sanui, Rui Tato Marinho, Jan Daniel, H Miranda, G. Williams, Éamon P McCarron, S. Simants, Imran Patanwala, Y. Su, J. Fernández Villanueva, Rita Fernandez Garda, A. López Lago, Esqué Ruiz, R. Hernández Vaquero, S. Tomé Martı́nez de Rituerto, Evaristo Varo Pérez, N. Lefel, Frank G. Schaap, D. C. J. J. Bergmans, Steven W.M. Olde Damink, Kate Tizard, Craig Lister, L. Poole, Donata Ringaitienė, D. Gineityte, Vaidas Vicka, Ieva Norkienė, Jūratė Šipylaitė, A. O’Loughlin, V. Maraj, Jane Dowling, D. M. Dalcomune, Edwin Dias, S. Fernandes, Taeyuki Oshima, S. Graf, Claudia‐Paula Heidegger, Laurence Genton, V.L. Karsegard, Y.M. Dupertuis, Claude Pichard, Natalie Friedli, Zeno Stanga, B. Mueller, L. Vandersteen, Susan Evers, A. Van Assche, Luc Jamaer, J. Valente, Paula Castelões, Claudia Christina Ribeiro Guimarães Neri de Magalhães, S. Cabral, Ângela Salgueiro, P. Martins, Sonia García Duarte, Sílvia Castro, Maria do Carmo Barros de Melo, A. Marinho, Sandra Gray, Kotchakorn Maipang, L. G. Grädel, Philipp Schütz, Pascal L. Langlois, William Manzanares, Madeleine E. Lemieux, Gunnar Elke, Frank Bloos, Konrad Reinhart, Ignacio Aramendi, Nuno Morais de Babo, Mozumi Hoshino, Y Haraguchi, Sohei Kajiwara, Takashi Mitsuhashi, Tohru Tsubata, Masahiko Aida, T. Rattanapraphat, Chanon Kongkamol, B. Xavier, Charilaos-Panagiotis Koutsogiannidis, M. Moschopoulou, Gürhan Taşkın, Mürteza Çakır, AK Güler, A. Taskin, Nesrin Öcal, Levent Yamanel, Jonathan Wong, C. Fitton, Sibtain Anwar, Sonya Stacey, Maria Aggou, B. Fyntanidou, Eirini Oloktsidou, K. Lolakos, E. Papapostolou, Satoshi Ono, Stèphane Gaudry, Victoire Desailly, Pierre Pasquier, P Brun, AT Tesnieres, JD Ricard, Alexandre Mignon, Jessica White, Alex Stilwell, Gilda Maria Souza Friedlaender, Megan E. Peters, Samuel Stipulante, Annick Delfosse, AF Donneau, Alexandre Ghuysen, C. Feldmann, D. Freitag, Wolfgang Dersch, Marc Irqsusi, Daphne Eschbach, Thorsten Steinfeldt, Hinnerk Wulf, Thomas Wiesmann, J. Cholkraisuwat, Sigrid Beitland, Espen Rostrup Nakstad, Henrik Stær-Jensen, Tomas Drægni, Geir Øystein Andersen, Dag Jacobsen, Cathrine Brunborg, Bård Waldum-Grevbo, Kjetil Sunde, Kimberley Hoyland, Debkumar Pandit, Kouichi Hayakawa, Katerina Kotzampassi, Lamprini Loukipoudi, E. Doumaki, Vasilis Grosomanidis, Marjolein M. Admiraal, M. Van Assen, M.J. van Putten, Marleen C. Tjepkema‐Cloostermans, Anne‐Fleur van Rootselaar, Francesca Ragusa, Andrea Marudi, Stefano Baroni, Ana Paula Gaspari, Elisabetta Bertellini, Taner Abdullah, Somaya Abdel Monem, Sean Alcorn, Stephanie McNeill, Scott A. Russell, Ward Eertmans, Cornelia Genbrugge, Ingrid Meex, Jo Dens, Frank Jans, C. De Deyne, Bronwyn Avard, Ryan Burns, A. Patarchi, Tullio Spina, Hiroyuki Tanaka, Norio Otani, Scott Ode, S. Ishimatsu, J. Cho, T. G. Ohk, M. C. Shin, Mi Hwa Won, S. Dakova, Z. Ramsheva, K. Ramshev, J. B. Moon, C. W. Park, Serra Sencer, Canan Ulusoy, Marika Fallenius, M.B. Skrifvars, M Reinikainen, Stepani Bendel, Rahul Raj, C. Hymers, Anna Borowska, H. Sivadhas, S. Sahiba, Sherry Perkins, J. A. Rubio, Shane English, Alexis F. Turgeon, A. Garland, Dean Fergusson, Alan Tinmouth, C. van Walraven, Kaitlyn Montroy, A. Dhaliwal, Cheemun Lum, J. Sinclair, Giuseppe Pagliarello, L. McIntyre, D. Griesdale, R. Zarychanski, T. Groza, Nicolas Moreau, Diego Castanares‐Zapatero, Philippe Hantson, Marco Carbonara, Fabrizio Ortolano, Tommaso Zoerle, Sandra Magnoni, S. Pifferi, V. Conte, Nino Stocchetti, Laurent Carteron, Tamarah Suys, Camille Patet, Hervé Quintard, Mauro Oddo, Věra Špatenková, Eva Pokorná, Petr Suchomel, N. Ebert, T. Bylinski, Christopher Hawthorne, Martin Shaw, Ian Piper, Aleah Kink, I. R. Rätsep, Amélie Boutin, François Lauzier, Paule Lessard-Bonaventure, R. Green, Mehmet Sarper Erdoğan, M. Butler, Philippe Desjardins, Bruno Gonçalves, Ben Vidal, C Valdez, Alice Cristina Rodrigues, Liliana Beatriz Miguez, Tae Hwa Hong, Alexander Kutz, Pierre Hausfater, D Amin, Tristan Struja, Sebastian Haubitz, Amy Huber, Thomas Brown, J Collinson, C. Pritchett, T. Slade, Morgan Le Guen, S. Hellings, Rollin A. Ramsaran, Ahmed Subhy Alsheikhly, Lina Kanapeckaite, M. Abu-Habsa, Rajiv Bahl, M. Q. Russell, Kevin Real, Richard Lyon, NP Oveland, Margaret McDonald, F. E. Kelly, M. Alfafi, Wasayf Saad Almutairi, B. Alotaibi, A.E. van den Berg, Y. Schriel, Luke Dawson, Iwan A. Meynaar, D. Silva, João Gouveia, J. Santos Silva, J. Foley, A. Kaskovagheorgescu, Denis Evoy, Jessica Cronin, Jeff Ryan, Matthias Huck, Clément Hoffmann, J K Renner, Philippe Laitselart, Nicolas Donat, A. Cirodde, J.-V. Schaal, Yannick Masson, Antoine Nau, O. J. R. Howarth, Katy Davenport, P. Jeanrenaud, S. Raftery, Pamela MacTavish, Malcolm Daniel, John Kinsella, S. Alrabiee, Azzam Alrashid, O. Gundogan, Canan Bor, E. Akýn Korhan, Kubilay Demırağ, Mehmet Uyar, Fiona M. Frame, Christopher Ashton, L. Bergstrom Niska, Pitchaya Dilokpattanamongkol, Thanarat Suansanae, C. Suthisisang, Sunthiti Morakul, Cherdkiat Karnjanarachata, Viratch Tangsujaritvijit, Sultan Mahmood, Hassan Al Thani, A. Almenyar, Sophie E. Morton, Yeong Shiong Chiew, J. Geoffrey Chase, G. M. Shaw, Peter Kordis, Vikas Grover, Iurii Kuchyn, K. Bielka, Zoi Aidoni, George Stavrou, S. Patsatzakis, C Skourtis, Sukkyoung Lee, I. D. Weltes, Sarah Berhane, C. Arrowsmith, Christine I. Peters, Simister Robert, Ronney B. Panerai, Thompson Robinson, E. Borg-Seng-Shu, M. De Lima Oliveira, N. Mian, Ricardo de Carvalho Nogueira, Manoel Jacobsen Teixeira, P. Killeen, Mark McPhail, William Bernal, Jennifer L. Maggs, J. Wendon, Tara Hughes, Leandro Utino Taniguchi, E. M. Siqueira, José Mauro Vieira, Luciano César Pontes Azevedo, A. N. Ahmad, E. Helme, Stephen J. Hadfield, Joanna Shak, C. Senver, Richard Howard-Griffin, Petch Wacharasint, Pusit Fuengfoo, Nares Sukcharoen, Ram Rangsin, D. Sbiti-Rohr, H. Na, Sun Ok Song, Shinwon Lee, Eun Joo Jeong, K. Lee, E. Zoumpelouli, V. Chrysohoidou, K. Charisopoulou, Eirini Kotzapanagiotou, K. Manavidou, Z. Stathi, Μαρία Σδούγκα, Bushra Alghamdi, Qussay Marashly, Khaled Zaza, M. Khurshid, Z. Ali, M. Malgapo, Mouhamad Ghyath Jamil, Azam Shafquat, M. Shoukri, May Hijazi, Francisco Airton Castro Rocha, Katia Ebecken, L. S. Rabello, Margarida Flor de Lima, R Hatum, Fernando V De Marco, AFF Alves, J. E. Pinto, Moacir Fernandes de Godoy, Pedro Emmanuel Alvarenga Americano do Brasil, Fernando A. Bozza, Jorge I. Salluh, Márcio Soares, James S. Krinsley, Gu Hyun Kang, Jeffrey J. Perry, Heather Findletar Hines, Kerri Wilkinson, C. Tordoff, B. Sloan, Mark C. Bellamy, E. Moreira, Marcelo Barbato, Usa Silva, André P. Torelly, Jeremy M. Kahn, Derek C. Angus, M. F. Knibel, R Marshall, Thomas Gilpin, D. Mota, Begoña Loureiro, J. Dias, O. Afonso, F. Coelho, A. Martins, Fábio Silva Faria, Haya Al Orainni, F. AlEid, H. Tlaygeh, A Itani, A. Hejazi, Jonathan Messika, Jean-Damien Ricard, S. Guillo, Blandine Pasquet, Emeline Dubief, Florence Tubach, Karen James, P Temblett, Lauren Davies, C. Lynch, Sérgio M. Pereira, Sara Cavaco, J. Fernandes, Isadora Alves Moreira, E. Almeida, F. Seabra Pereira, M. Malheiro, F. Cardoso, Irene Aragão, Teresa Cardoso, Misa Fister, P. Muraray Govind, N. Brahmananda Reddy, R. Pratheema, E. D. Arul, J. Devachandran, Nicolas Chin‐Yee, Gianni D’Egidio, Kednapa Thavorn, Daren K. Heyland, Kwadwo Kyeremanteng, Andrew G. Murchison, K. Swalwell, Jessica A. Mandeville, Dawn Stott, I. Guerreiro, Helen Devine, Chloë Goossens, Marisa B. Marques, Sarah Derde, Sarah Vander Perre, Thomas Dufour, Steven Thiessen, Fabián Güiza, Thomas Janssens, Greet Hermans, Ilse Vanhorebeek, Katrien De Bock, Greet Van den Berghe, Lies Langouche, Barbara Miles, Sharen Madden, Mary Weiler, Patrícia Figueiredo Marques, Camila Eleutério Rodrigues, M. Boeira, K. Brenner, Clarissa Garcia Soares Leães, André Sant′Ana Machado, R. Townsend, J. Andrade, R. Kishore, Christine M. Fenlon, T. Fiks, A. de Ruijter, M. Te Raa, Peter E. Spronk, Paul D. Docherty, Jennifer L. Dickson, Elena Moltchanova, C. Scarrot, Timothy J. Hall, W. C. Ngu, Justin Jack, Androula Pavli, X. Gee, Esra Akın Korhan, Mohamed Shirazy, AM Fayed, Samiksha Gupta, Anjali Kaushal, Sandeep Dewan, Amit Varma, E. Ghosh, Lei Yang, Larry J. Eshelman, Bill Lord, Eric T. Carlson, R. Broderick, D. Forte, F. Yang, James M. Feeney, Kris Bauchmüller, K. Shuker, Matthew Faulds, Daniele Bryden, Lauren England, Karen Shuker, Amy Matheson, J. William Gaynor, B. Peroni, Roger D. Dias, Layse Siqueira Costa Miranda, Charlotte Cohen, Carlos Roberto Ribeiro de Carvalho, I. T. Velasco, J. M. Kelly, Alister Neill, Gordon D. Rubenfeld, N. Masson, Ari Min, Edwin J. Boezeman, J Hofhuis, Aly Hovingh, Ralph de Vries, G. Cabral-Campello, Margo van Mol, Marjan D. Nijkamp, Erwin J. O. Kompanje, P. Ostrowski, K Kiss, Béla Köves, Valér Csernus, Zsolt Molnár, Y. Hoydonckx, S. Vanwing, V. Medo, Rosario Barrera Gálvez, J. P. Miranda, Charles K. Stone, Timothy Wigmore, Y. Arunan, A. Wheeler, Adrian Wong, Choo Hwee Poi, Carol Gu, P. Molmy, Nicolas Van Grunderbeeck, Olivier Nigeon, Malcolm Lemyze, Didier Thévenin, Jihad Mallat, Maryam Correa, Raquel Carvalho, Analía Fernández, Craig A. McBride, E. Koonthalloor, Cathal Walsh, Ann Webber, Maureen C. Ashe, Kirsten V. Smith, Meropi Dimitriadou, Peristera-Eleni Mantzafleri, O. Vrani, A. Arbouti, T. Varsami, Jan Bollen, Tim C. van Smaalen, W. C. De Jongh, M.M. ten Hoopen, Dirk Ysebaert, L. W. Van Heurn, Walther N. van Mook, Amanda Roze des Ordons, Philippe Couillard, Christopher J. Doig, Rose‐Lima Van Keer, Reginald Deschepper, A Francke, Luc Huyghens, J. B. Bilsen, B. Nyamaizi, C. Dalrymple, A. Dobru, E. Marrinan, A. Ankuli, R. Struthers, Rebecca Crawford, Tara Quasim, P Morelli, M. Degiovanangelo, Felipe Kesrouani Lemos, Victoria Jimenez Martinez, J. L. Santana Cabrera, A Rutten, S. Van Ieperen, Sabrina Geer, Marieke K. van Vugt, E. Der Kinderen, Alberto Giannini, Guido Miccinesi, Tiziana Marchesi, Edi Prandi
Bibliographic record
VenueCritical Care · 2016
Typearticle
Languageen
FieldMedicine
TopicSepsis Diagnosis and Treatment
Canadian institutionsThe Scarborough HospitalSunnybrook Health Science CentreUniversité de MontréalUniversity of ManitobaUniversité LavalUniversity of British ColumbiaUniversity of British Columbia HospitalHealth Sciences CentreUniversity Health NetworkOttawa HospitalUniversité de SherbrookeUniversity of TorontoWestern UniversityHôpital du Sacré-Cœur de MontréalToronto General HospitalDalhousie UniversityQueen's UniversitySt. Paul's HospitalUniversity of CalgaryKingston General HospitalMount Sinai Hospital
FundersFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
KeywordsSepsisMedicineLeukopeniaInternal medicineGastroenterologyToxicity
Abstract
Introduction: Intravenous(IV) immunoglobulin(Ig) treatment is known to alleviate behavioral deficits in the experimentally induced model of sepsis.To delineate the mechanisms by which IVIg treatment prevents neuronal dysfunction, an array of immunological and apoptosis markers was investigated.Methods: Sepsis was induced by cecal ligation perforation(CLP) in rats.The animals were divided into five groups; sham, control, CLP + saline, CLP + immunoglobulin G IgG(250 mg/kg,iv), and CLP + immunoglobulins enriched with immunoglobulin M-IgGAM(250 mg/kg,iv).Blood and brain samples were taken in two sets of experiments after CLP to see the early(24 hrs) and late(10 days) effects of treatment.Total complement activity, complement 3(C3) and soluble complement C5b-9 levels were measured in sera of rats using ELISA-based methods.Cerebral complement content was analyzed by Western Blot.Immune cell infiltration and gliosis were examined by immunohistochemistry using cluster of differentiation 3, CD4, CD8, CD11b, CD19 and glial fibrillary acidic protein antibodies.Apoptotic neuronal death was investigated by TUNEL staining and Western Blot-based semi-quantitative evaluation of brain homogenates by bax and bcl-2 antibodies.Results: IV IgG and IgGAM administration significantly reduced systemic complement activity but increased serum C3 and soluble C5b-9 levels.Likewise, Western Blot data showed slightly increased C5b-9 expression and significantly reduced C1q expression in brain samples of IgGAM-treated but not IgG-treated septic rats especially in the first day of administration.No cerebral cellular infiltrates were observed in treated and non-treated septic rats.By contrast, IV IgG and IgGAM treatment induced considerable amelioration in glial cell proliferation which was increased in non-treated rats.IgG and IgGAM treated rats exhibited significantly reduced numbers of apoptotic neurons and cerebral expression levels of bax and bcl-2 as compared to nontreated rats.Conclusions: We suggest that IV IgG and IgGAM administration ameliorates neuronal dysfunction and behavioral deficits by reducing apoptotic cell death and glial cell proliferation.IgGAM treatment might be suppressing classical complement pathway by reducing C1q expression.P004
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.075
Threshold uncertainty score0.250
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.002 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.001 | 0.002 |
| Research integrity | 0.002 | 0.002 |
| Insufficient payload (model declined to judge) | 0.075 | 0.040 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.082
GPT teacher head0.402
Teacher spread0.321 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations521
Published2016
Admission routes1
Has abstractyes