Increase Alginate-Chitosan Nanoparticles Transport Efficiency Through the Epithelium by Attaching nt-PE onto Surface
Bibliographic record
Abstract
Nanotechnology has brought drug delivery system into a brand new age---the appearance of Nano delivery system. It has been widely explored in different therapeutic areas. For oral protein delivery, the application of Nano delivery system is limited by the low transport efficiency through the epithelium in the small intestine. The efficient transport of nano delivery system through epithelium requires optimized surface characteristics and specific transport pathway. In this study, chitosan and alginate are chosen for making nanoparticles, as they are bioadhensive, biodegradable and can be modified for the surface modification. The pathway of nanoparticles go across the epithelium is designed to mimic the pathway of virus invasion in the body. Study has shown non-toxic form of pseudomonas exotoxin (nt-PE) can go across the polarized cells (epithelial cells) Our hypothesis is that the transport efficiency of alginate-chitosan nanoparticles through the epithelium can be increased after attaching nt-PE onto the surface.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.002 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.002 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".