Polysaccharide-Based Hydrogels for Tissue Engineering
Bibliographic record
Abstract
Polysaccharide is one of widely utilized materials in biomedical areas due to its excellent biocompatibility. However, most polysaccharide-based hydrogels are typically prepared in the presence of excipient chemical reagents that may cause toxicity. In this presentation, we report how hyaluronate hydrogels can be prepared without toxic chemical cross-linking agents. Hyaluronate is composed of -1,4-D-glucuronic acid--1,3-N-acetyl-D-glucosamine residues, and is abundant in synovial fluid and extracellular matrix. We introduced alginate to the hyaluronate backbone, allowing gel formation in the presence of calcium ions The mechanical properties of hydrogels were varied depending on type and concentration of polysaccharide. Tissue regeneration using these hydrogels were carried out by subcutaneous injection of primary chondrocyte/hydrogel constructs into a mouse model.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".