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Record W2546813772 · doi:10.1016/j.eururo.2016.10.013

Translating a Prognostic DNA Genomic Classifier into the Clinic: Retrospective Validation in 563 Localized Prostate Tumors

2016· article· en· W2546813772 on OpenAlexafffund
Emilie Lalonde, Rached Alkallas, Melvin L.K. Chua, Michael Fraser, Syed Haider, Alice Meng, Junyan Zheng, Cindy Q. Yao, Valérie Picard, Michèle Orain, Hélène Hovington, Jure Murgić, Alejandro Berlín, Louis Lacombe, Alain Bergeron, Yves Fradet, Bernard Têtu, Johan Lindberg, Lars Egevad, Henrik Grönberg, Helen Ross‐Adams, Alastair Lamb, Silvia Halim, Mark Dunning, David E. Neal, Melania Pintilie, Theodorus van der Kwast, Robert G. Bristow, Paul C. Boutros

Bibliographic record

VenueEuropean Urology · 2016
Typearticle
Languageen
FieldMedicine
TopicProstate Cancer Diagnosis and Treatment
Canadian institutionsToronto General HospitalUniversity of TorontoUniversity Health NetworkUniversité LavalPrincess Margaret Cancer CentreOntario Institute for Cancer Research
FundersCanadian Institutes of Health ResearchProstate Cancer UKAcademy of Medical SciencesNational Institute for Health and Care ResearchCancer Research UK
KeywordsMedicineProstate cancerProstatectomyBiochemical recurrenceHazard ratioLocus (genetics)Retrospective cohort studyOncologyInternal medicineMetastasisProportional hazards modelClassifier (UML)Confidence intervalGeneCancerArtificial intelligenceGeneticsBiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.056
Threshold uncertainty score0.409

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.276
Teacher spread0.253 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations41
Published2016
Admission routes2
Has abstractno

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