Systemic Lupus Erythematosus — Basic, Applied, and Clinical Aspects
Bibliographic record
Abstract
Systemic lupus erythematosus (SLE) is a complex autoimmune disease with many clinical manifestations that lead to significant morbidity and mortality.The textbook, Systemic Lupus Erythematosus -Basic, Applied, and Clinical Aspects, was written as a thorough examination of the historic, pathogenetic, clinical, and treatment dimensions of SLE.Each of these topics is divided into sections, with detailed chapters within each section.Each chapter was written by an international panel of experts in that particular topic as it relates to SLE.The beginning of the text discusses the many theories surrounding the pathogenesis of SLE; specifically, the immunological derangements and how they affect the clinical symptoms seen in most patients.For those not well versed in the nuances of immunology, these chapters are thorough and exhaustive in detail, but comprehensible.A summary section is included at the end of each chapter and has a 2-fold purpose: as a great synopsis to highlight the important aspects of the chapter, or as a substitute for reading the entire chapter.It is enjoyable to read the clinical pearls presented by the authors in relation to disease monitoring using the SLE Disease Activity Index and/or the British Isles Lupus Assessment Group index, as well as current and potential treatment options.The chapters dedicated to potential treatment options were well written -they connected the basic immunology discussed in earlier chapters to potential pharmaceutical targets.This textbook is recommended because it is a valuable resource for beginning and seasoned rheumatologists.Additionally, it could serve as a basis for those engaging in basic science projects surrounding the pathogenesis of SLE.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.004 | 0.003 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.012 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".