Genetic variation in salt taste receptors impact salt intake, blood pressure and cardiovascular disease risk factors in the Guelph Family Health Study
Bibliographic record
Abstract
The objective of this thesis was to investigate polymorphisms found in salt taste receptors on dietary sodium intake, blood pressure and cardiovascular disease (CVD) risk factors in children and parents of the Guelph Family Health Study (GFHS). The study was a cross-sectional analysis of 70 families (children, n=95 and parents, n=117). A primary finding showed that children, T allele carriers of the rs239345 (A>T) polymorphism consumed 34% more sodium than the AA genotype. Child and female adult carriers of the T allele of the rs8065080 (C>T) polymorphism consumed 21% and 41% lower amounts of sodium respectively. Findings show that genetic polymorphisms in genes SCNN1b and TRPV1 may influence sodium consumption and CVD risk in adults and children.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".