Real-time imaging, targeting, and ablation of ex-vivo tissue using a handheld histotripsy transducer and coregistered 64-element high-frequency endoscopic phased array
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
In this work, we have developed a small, handheld histotripsy transducer where the ablation focus is imaged in real-time using a co-registered 45 MHz 64-element phased array endoscope. The construction of a 2 cm diameter, 40% volume fraction, strongly curved, PZT5A composite transducer capable of generating cavitation within tissue is outlined. The co-registered imaging and ablation tool was able to ablate a 1 mm x 0.5 mm × 0.5 mm volume below the surface of a chinchilla brain using a single 5 second, 1 kHz PRF, 10 cycle burst, without damage to the surface leading to the ablation site. Total electrical power draw during treatment was less than 4 W.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it