The Effects of High Dose Corticosteroids for MS Relapse on Blood Pressure: A Pilot Study (P2.089)
Bibliographic record
Abstract
Objective: To determine the effect of high dose corticosteroids (CR) for MS relapses on blood pressures (BP). Background: When used chronically in low doses CR is known to increase BP. Data is limited regarding the effects on BP of high dose CR used for acute MS relapses. Methods: Consecutive MS patients with an acute relapse requiring CR treatment measured oscillometric BP with 24-hour ambulatory BP monitor (ABP) or using home BP monitoring (HBP) for the duration of CR treatment; ABP was set to measure hourly during waking (09:00-21:00) and two-hourly nocturnally (23:00-06:00). Subjects using HBP were asked to measure several times a day, before bed and upon awakening anytime at night and in the morning. Demographic information, pre-CR blood work for electrolytes and kidney function were recorded. Generalized linear model for repeat measures analysis was used to examine changes in BP. Results: 24 subjects enrolled. The majority were female (21, 87.5[percnt]) with mean age of 40.7 years; 5 (20.8[percnt]) had a history of hypertension (HTN) while 11 (45.8[percnt]) had a history of HTN in a first degree relative. GLM found a significant within group (p=0.019), between group (p=0.003) change, as well as interaction for daytime systolic BP for subjects with a history of HTN (p=0.007) or a family history of HTN (p=0.037). There was no significant within group (p=0.506) change in night-time diastolic BP, suggesting the expected nocturnal dip in diastolic BP was lost. Conclusions: MS patients treated with high dose CR for relapses lose the expected nighttime diastolic BP decrease. Further, those with a history or family history of HTN show a significant increase in systolic BP. Loss of nocturnal dip correlates with a significant increase in stroke risk. This pilot data suggests high dose CR treatment for MS relapses may have implications for cerebrovascular and cardiovascular health.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".