PO-36 EFFECTS OF FIXED VERSUS AUTO-TITRATING CONTINUOUS POSITIVE AIRWAY PRESSURE ON VASCULAR FUNCTION IN PATIENTS WITH RESISTANT HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
Bibliographic record
Abstract
Introduction: Calcium intake, recommended for osteoporosis prevention, has been associated with cardiovascular (CV) outcomes.We examined the association of dietary calcium intake (dCa) with surrogate CV markers, including carotid intima-media thickness (cIMT), arterial stiffness and hemodynamics in healthy postmenopausal women.Methods: Healthy postmenopausal women without any CV risk factors, from a randomized controlled trial studying the effect of calcium supplementation vs. dietary calcium on vascular heath, were recruited.Cross-sectional analyses of baseline data of the participants are presented.Peripheral systolic and diastolic blood pressures (pSBP, pDBP) were measured by BpTRU.cIMT of both common-carotid arteries was measured by B-mode ultrasonography (Philips-iU22).Arterial stiffness (carotid-to-femoral pulse wave velocity [cfPWV] and carotidto-radial PWV), central SBP and DBP (cSBP, cDBP), mean arterial pressure (MAP), and hemodynamic parameters (pulse pressure, augmentation pressure, augmentation index corrected for 75 bpm) were obtained non-invasively (Sphyg-moCor).Usual dCa intake was estimated using a validated food frequency questionnaire.Measurements were compared across groups (<600, 600-1000 and >1000 mg/day of dCa) by one-way analysis of variance and covariance.Results: We evaluated 83 postmenopausal women (mean age 60.4AE6.3years; BMI 25.6AE3.8kg/m 2 ).Mean dCa was 857AE333 mg/day.Although within normal range, vascular parameters had a non-significant, U-shaped relationship with dCa.In unadjusted analyses, women with dCa >1000 mg/day had significantly higher cfPWV, pSBP, cSBP, and MAP compared to those with 600-1000 mg/day; however, significance was lost for all other parameters except for MAP after adjustment for pertinent covariates (Table ).Conclusion: In healthy postmenopausal women, a non-significant, U-shaped relationship of vascular parameters across the 3 dCa groups was noted; dietary calcium may have favourable effect on MAP for those consuming 600-1000 mg/day compared to >1000 mg/day intake.Of note, our population had optimal/normal BP.Our ongoing study including a larger sample-size will determine the relationship between dCa and surrogate CV markers.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".