Classification of HIV data by constructing a social network with frequent itemsets
Bibliographic record
Abstract
Acquired immune deficiency syndrome (AIDS) is the last and the most life-threatening phase of Human Immunodeficiency Virus (HIV) disease. HIV attacks and heavily affects the immune system of the body which remains unable to resist the disease. HIV uses white blood cells to replicate itself and spreads everywhere in the body. The lifecycle of HIV disease, especially the replication stage must be prominently understood in order to develop effective drugs for treatment. HIV-1 protease enzyme is in charge of cleaving an amino acid octamer into peptides which are used to create proteins by virus. It should be scrutinized properly since it is a potential target to tightly bind drugs to protease for blocking the virus action at an early stage before cell infection. It is very critical to induce a model and predict cleavage of HIV-1 protease on octamers. Several machine learning approaches have been applied for predicting and profiling cleavage rules. However, we propose a novel general approach that can also be applied on different domains. It basically utilizes social network analysis and data mining techniques for classification. This method yet presents promising results that are comparable with existing machine learning methods, besides it gives the opportunity to validate the results obtained by using other techniques from social network analysis perspective. We have used the HIV-1 protease cleavage data set from UCI machine learning repository and demonstrated the effectiveness of our proposed method by comparing it with decision tree, Naive-Bayes and k-nearest neighbor methods.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.004 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.010 | 0.004 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".