Therapeutic Potential of CXCR4/SDF-1 Axis in Acute Myocardial Infarction
Bibliographic record
Abstract
Acute Myocardial Infarction (AMI) is one of the mortal diseases which relate to heart and has many impacts on patients’ life. Stem cell therapy, including mesenchymal stem cells (MSCs), has emerged a promise treatment for patients with this disease. However, the inefficient migration and homing of MSCs have limited their therapeutic applications. It has been demonstrated that CXCR4/SDF-1 axis has a crucial role in cell migration and stem cell homing. So, many studies have conducted and currently are operating by novel methods to improve homing of MSCs by up-regulating the expression of CXCR4/SDF-1 axis to discover a proper cell therapy for AMI. CXCR4/SDF-1 axis triggers a variety of biological responses, such as directing cell migration, organogenesis, hematopoiesis, vascularization, and immune responses. Therefore, this axis might be a good candidate for manipulation with therapeutic purposes.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".