DIABLO - an integrative, multi-omics, multivariate method for multi-group classification
Bibliographic record
Abstract
Rapid advances in technology have led to a wealth of large-scale molecular omics datasets. Integrating such data offers an unprecedented opportunity to assess molecular interactions at multiple functional levels and provide a more comprehensive understanding of the biological pathways involved in different diseases subgroups. However, multiple omics data integration is a challenging task due to the heterogeneity in the different platforms used. There is a need to address the complex and correlated nature of different data-types, in order to identify a robust and reliable multi-omics signature that can predict a phenotype of interest. We introduce a novel multivariate dimension reduction method for multiple omics integration, classification and identification of a multi-omics molecular signature. DIABLO - Data Integration Analysis for Biomarker discovery using a Latent component method for Omics studies, models the correlation structure between omics datasets, resulting in an improved ability to associate biomarkers across multiple functional levels to phenotypes of interest. We demonstrate the capabilities of DIABLO using simulated data and studies of breast cancer and asthma, integrating up to four types of omics datasets to identify relevant biomarkers, while still retaining competitive classification and predictive performance compared to existing methods. Our statistical integrative framework can benefit a diverse range of research areas with varying types of study designs, as well as enabling module-based analyses. Importantly, graphical outputs of our method assist in the interpretation of such complex analyses and provide significant biological insights.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.012 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.003 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.002 | 0.003 |
| Research integrity | 0.001 | 0.003 |
| Insufficient payload (model declined to judge) | 0.005 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".