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Record W2553175169 · doi:10.1002/adhm.201670122

Cell Therapy: In Vitro Topographical Model of Fuchs Dystrophy for Evaluation of Corneal Endothelial Cell Monolayer Formation (Adv. Healthcare Mater. 22/2016)

2016· article· en· W2553175169 on OpenAlexaff
Muhammad Rizwan, Gary S. L. Peh, Khadijah Adnan, Sacha L. Naso, Alon R. Mendez, Jodhbir S. Mehta, Evelyn K. F. Yim

Bibliographic record

VenueAdvanced Healthcare Materials · 2016
Typearticle
Languageen
FieldMedicine
TopicCorneal Surgery and Treatments
Canadian institutionsUniversity of Waterloo
Fundersnot available
KeywordsBasement membraneCorneal diseaseDystrophyIn vitroCorneal dystrophyCorneal endotheliumCell biologyCorneaMonolayerCellBlindnessChemistryOphthalmologyMedicinePathologyBiologyOptometryBiochemistry

Abstract

fetched live from OpenAlex

Micro-structural changes in the corneal endothelial basement membrane cause Fuchs dystrophy, which leads to corneal blindness. On page 2896, Muhammad Rizwan and co-workers demonstrate a micro-fabricated in vitro disease model of Fuchs dystrophy by recapitulating the topographical details of diseased basement membrane. This model is employed to elucidate complex interaction of corneal cells with the disease-like surface to study corneal endothelial monolayer reformation for the development of corneal cell regenerative therapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.038
Threshold uncertainty score0.772

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.049
GPT teacher head0.329
Teacher spread0.280 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractyes

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