Forkhead box protein‐3 (Foxp3)‐producing dendritic cells suppress allergic response
Bibliographic record
Abstract
Abstract Background The generation of the tolerogenic dendritic cells ( DC ) is not fully understood yet. Forkhead box protein‐3 (Foxp3) is an important molecule in the immune tolerance. This study tests a hypothesis that DC s express Foxp3, which can be upregulated by Staphylococcal enterotoxin B ( SEB ). Methods The expression of Foxp3 by DC s was evaluated by real‐time RT ‐ PCR , Western blotting, flow cytometry, and chromatin immunoprecipitation assay. Results We observed that mice treated with SEB at 0.25–0.5 μg/mouse showed high frequencies of transforming growth factor ( TGF )‐β‐producing CD 4 + T cells and TGF ‐β‐producing DC s in the intestine, while the IL ‐4 + CD 4 + T cells and TIM 4 + DC s were dominated in the intestine in mice treated with SEB at 1–10 μg/mouse. Treating DC s with SEB in the culture induced high levels of Foxp3 at the TGF ‐β promoter locus. The function of Foxp3 was blocked by STAT 6 (signal transducer and activator transcription‐6); the latter was induced by exposing DC s to SEB in the culture at doses of 100–400 ng/ml. Treating allergic mice with specific immunotherapy ( SIT ) together with SEB significantly promoted the therapeutic effects on the allergic responses than treating with SIT alone. Conclusion Dendritic cells have the capacity to express Foxp3, which can be upregulated by exposure to SEB .
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; both teacher heads agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".