Bibliographic record
Abstract
into the patients T cells. The second format is based on antibody fragments fuse with a cytotoxic T cell signaling molecule. Our laboratory isolated antibodies that recognize MHC-peptide complexes. Such TCR-like antibodies exhibit both binding properties and kinetics of antibodies (e.g. high affinity), and mimic the specificity of TCRs. We isolated a TCR-like antibody, termed F2, which recognizes an HLA-A2/wt1-derived peptide complexes expressed on the surface of leukemia cells. By Using this F2 Fab, which exhibits specificity of TCR, we were able to properly compare the biological functions of TCR-based vs. TCR-like-antibody-based engineered T cells. This comparison reveals which chimeric receptor format is superior in mediating the cytotoxic function of T cells, and may also lead to a better understanding of the mechanisms of T-cell recognition elements.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.038 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".