First structure of a cGMP-dependent protein kinase
Why this work is in the frame
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Bibliographic record
Abstract
PKA and PKG are two of the eponymous members of the AGC family of protein kinases as well as two of the earliest protein kinases discovered. Due largely to contributions from structural biology, the mechanism of cooperative and allosteric regulation of PKA is well understood. On the other hand, no structure of PKG from any organism has been available until recently. We present the first ever structure of PKG from the malaria parasite Plasmodium falciparum. The structure features PKG in its auto-inhibited form - a pentagonal arrangement of 4 cGMP-binding sites and the catalytic kinase domain. By comparing of this structure with PKA structures, we propose a novel mechanism of cooperativity and allostery by which Plasmodium PKG is regulated.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it