Structural Characterization of PLZF-Corepressor Complexes
Bibliographic record
Abstract
Promyelocytic Leukemia Zinc Finger (PLZF) encodes a transcription factor containing an N-terminal BTB domain as well as 9 C-terminal C2H2 Zinc Finger repeats. PLZF represses genes necessary for the differentiation of haematopoietic progenitors as well as spermatogonia and therefore plays a crucial role in stem cell renewal. It accomplishes this by recruiting large, multi-protein repressor complexes to its targets genes. In order to understand the structural behavior of PLZF within the context of these complexes, we are employing a multi-disciplinary approach to identify proteins involved in direct interactions with PLZF, including the use of a loss of function mutation within the BTB domain. Our data identifies known corepressors Sin3A, SMRT, HOXA5 and other members of HDAC complexes family as potential direct interacting partners. Progress towards solving the crystal structure of the PLZF BTB domain bound to its corepressors will be presented.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".