Regulation of activity-dependent protein synthesis in dendrites (Abstract)
Bibliographic record
Abstract
Protein synthesis in dendrites is essential for long-lasting synaptic plasticity, but little is known about how synaptic activity is coupled to mRNA translation. Using hippocampal neuron cultures and slices, we have investigated the role of glutamate receptors and mTOR signaling in control of dendritic protein synthesis. We find: 1) Specific antagonists of NMDA, AMPA and metabotropic glutamate receptors abolish glutamate-induced dendritic protein synthesis, whereas agonists of NMDA and metabotropic but not AMPA glutamate receptors activate protein synthesis in dendrites; 2) Inhibition of mTOR signaling, as well as its upstream activators, PI3K and AKT, block NMDA receptor-dependent dendritic protein synthesis. Conversely, activation of mTOR signaling induces dendritic protein synthesis; and 3) Dendritic protein synthesis activated by tetanus-mediated LTP induction in hippocampal slices requires NMDA receptors and mTOR signaling. These results suggest critical role of the NMDA receptor-mTOR signaling pathway in regulating protein synthesis in dendrites of hippocampal neurons.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.003 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".