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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): late breaking abstracts
Sonja Althammer, Keith E. Steele, Marlon C. Rebelatto, Tze Heng Tan, Tobias Wiestler, Guenter Schmidt, Brandon W. Higgs, Xia Li, Li Shi, Xiaoping Jin, Joyce Antal, Ashok Gupta, Koustubh Ranade, Gerd Binning, Joaquim Bellmunt, Ronald de Wit, David J. Vaughn, Yves Fradet, Jae‐Lyun Lee, Lawrence Fong, Nicholas J. Vogelzang, Miguel Ángel Climent, Daniel P. Petrylak, Toni K. Choueiri, Andrea Necchi, Winald R. Gerritsen, Howard Gurney, David I. Quinn, Stéphane Culine, Cora N. Sternberg, Yabing Mai, Markus Puhlmann, Rodolfo F. Perini, Dean F. Bajorin, Padmanee Sharma, Margaret K. Callahan, Emiliano Calvo, Joseph W. Kim, Filipo de Braud, Patrick A. Ott, Petri Bono, Rathi N. Pillai, Michael A. Morse, Dung T. Le, Matthew H. Taylor, Pavlina Spilliopoulou, Johanna C. Bendell, Dirk Jaeger, Emily Chan, Scott Antonia, Paolo A. Ascierto, Delphine Hennicken, Marina Tschaika, Alex Azrilevich, Jonathan E. Rosenberg, Ofer Levy, Christopher J. Chan, Gady Cojocaru, Spencer C. Liang, Eran Ophir, Sudipto Ganguly, Amir Toporik, Maya F. Kotturi, Tal Fridman Kfir, Benjamin Murter, Kathryn Logronio, Liat Dassa, Ling Yan Leung, Shirley Greenwald, Meir Azulay, Sandeep Kumar, Zoya Alteber, Xiaoyu Pan, Arthur Machlenkin, Yair Benita, Andrew W. Drake, Ayelet Chajut, Ran Salomon, Ilan Vankin, Einav Safyon, John Hunter, Zurit Levine, Mark White, Rom S. Leidner, Hyunseok Kang, Robert I. Haddad, Neil H. Segal, Lori J. Wirth, Robert L. Ferris, F. Stephen Hodi, Rachel E. Sanborn, Thomas F. Gajewski, William H. Sharfman, Dan McDonald, Shivani Srivastava, Xuemin Gu, Penny Phillips, Chaitali Passey, Tanguy Y. Seiwert, Tsadik Habtetsion, Gang Zhou, Donastas Sakellariou-Thompson, Cara Haymaker, Caitlin Creasy, Mark W. Hurd, Naohiro Uraoka, Jaime Rodriguez Canales, Scott Koptez, Patrick Hwu, Anirban Maitra, Chantale Bernatchez, Scott M. Coyle, Kole T. Roybel, Levi J. Rupp, Stephen P. Santoro, Stephanie Secrest, M. S. Spelman, Hanson Ho, Tina Gomes, Tiffany Tse, Chia Yung-Wu, Jack Taunton, Wendell A. Lim, Peter Emtage, Tarsem Moudgil, Carmen Ballesteros‐Merino, Traci Hilton, Christopher Paustian, David Page, Walter J. Urba, Bernard A. Fox, R. Bryan Bell, Ashish Patel, Tove Olafsen, Daulet Satpayev, Michael Torgov, Filippo Marchioni, Jason M. Romero, Ziyue Karen Jiang, Charles Zamilpa, Jennifer Keppler, Alessandro Mascioni, Fang Jia, Chenyu Lee, Jean Gudas, Ryan J. Sullivan, Yujin Hoshida, Theodore F. Logan, Nikhil I. Khushalani, Anita Giobbie‐Hurder, Kim Margolin, Joanna Roder, Rupal S. Bhatt, Henry Koon, Thomas Olencki, Thomas E. Hutson, Brendan D. Curti, Shauna Blackmon, James W. Mier, Igor Puzanov, Heinrich Röder, John H. Stewart, Asim Amin, Marc S. Ernstoff, Joseph I. Clark, Michael B. Atkins, Howard L. Kaufman, Jeffrey A. Sosman, Sabina Signoretti, David F. McDermott, Abraham Anderson, Mohammed Milhem, Robert H.I. Andtbacka, David R. Minor, Kevin Gorski, Daniel M. Baker, Omid Hamid, Emmanuel T. Akporiaye, Yoshinobu Koguchi, Kim Sutcliffe, Kristie Conder, Thomas U. Marron, Nina Bhardwaj, Linda Hammerich, Fiby George, Seunghee Kim‐Schulze, Tibor Keler, Elizabeth Crowley, Andres Μ. Salazar, Joshua Brody, Arta M. Monjazeb, Megan E. Daly, Jonathan W. Riess, Tianhong Li, William J. Murphy, Karen Kelly, Zhiwei Hu, Rulong Shen, Amanda Campbell, Elizabeth L. McMichael, Lianbo Yu, Bhuvaneswari Ramaswam, Cheryl A. London, Tian Xu, William E. Carson, Kathleen M. Kokolus, Elizabeth A. Repasky, Todd D. Schell, Joseph D. Drabick, David J. Messenheimer, Shawn M. Jensen, B. Fox, Mark P. Rubinstein, Kristina Andrijauskaite, Marzena Swiderska‐Syn, Kristin Lind, Agnès Choppin, Marina K. Roell, John Wrangle, Peter R. Rhode, Hing C. Wong, Shamim Ahmad, Mason Webb, Rasha Abu Eid, Rajeev Shrimali, Vivek Verma, Atbin Doroodchi, Zuzana Berrong, David Yashar, Raed Samara, Mikayel Mkrtichyan, Samir N. Khleif, Steven Powell, Mark M. Gitau, Christopher Sumey, Andrew M. Terrell, Michele Lohr, Ryan K. Nowak, Steven McGraw, Ash Jensen, Miran Blanchard, Kathryn A. Gold, Ezra E.W. Cohen, Christie Ellison, Lora Black, William C Spanos, Erik Wennerberg, Emily Schwitzer, Claire Lhuillier, Graeme J. Koelwyn, Rebecca L. Hiner, Lee W. Jones, Sandra Demaria, Vandeveer Amanda, John W. Greiner, Jeffrey Schlom, Michelle L. Bookstaver, Christopher M. Jewell, Andrew J. Gunderson, Brian C. Boulmay, Rui Li, Bradley Spieler, Kyle Happel, Zipei Feng, Christopher Dubay, Brenda Fisher, Sandra Aung, Eileen Mederos, Carlo Bifulco, Michael McNamara, Keith S. Bahjat, William L. Redmond, Augusto C. Ochoa, Hong‐Ming Hu, Adi Mehta, Fridtjof Lund‐Johansen, Frank Bedu‐Addo, Greg Conn, Michael King, Panna Dutta, Robert Shepard, Mark H. Einstein, Sylvia Adams, Ena Wang, Ping Jin, Yelena Novik, D. Morrison, Ruth Oratz, Franco Marincola, David F. Stroncek, Judith D. Goldberg, Silvia C. Formenti, Jérôme Galon, Bernhard Mlecnik, Florence Marliot, Fang‐Shu Ou, Alessandro Lugli, Inti Zlobec, Tilman T. Rau, Irıs D. Nagtegaal, Elisa Vink‐Börger, Arndt Hartmann, Carol Geppert, Michael H. A. Roehrl, Prashant Bavi, Pamela S. Ohashi, Julia Y. Wang, Linh T. Nguyen, SeongJun Han, Heather MacGregor, Sara Hafezi‐Bakhtiari, Bradley Wouters, Yutaka Kawakami, Boryana Papivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Kyogo Itoh, Eva Závadová, Michal Vočka, Jiří Špaček, Luboš Petruželka, B Konopásek, Pavel Dundr, Helena Skálová, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Marc Van den Eynde, Anne Jouret‐Mourin, Jean‐Pascal Machiels, Tessa Fredriksen, Lucie Lafontaine, Bénédicte Buttard, S. Church, Pauline Maby, Helen K. Angell, Mihaela Angelova, Angela Vasaturo, Gabriela Bindea, Anne Berger, Christine Lagorce, Prabhudas S. Patel, Hemangini H. Vora, Birva Shah, Jayendrakumar B. Patel, Kruti N. Rajvik, Shashank Pandya, Shilin N. Shukla, Yili Wang, Guanjun Zhang, Giuseppe Masucci, Emilia Andersson, Fabio Grizzi, Luigi Laghi, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Cilberto, Daniel J. Sargent, Alain P. Algazi, Katy K. Tsai, Michael Rosenblum, Prachi Nandoskar, Amy Li, John Nonomura, Kathryn T. Takamura, Mary A. Dwyer, Erica Browning, Reneta Talia, Chris Twitty, Sharron Gargosky, Jean Campbell, Mai Quynh Le, Robert H. Pierce, Adil Daud, Robyn D. Gartrell, Douglas K. Marks, Edward C. Stack, Yan Lu, Daisuke Izaki, Kristen Beck, Dan Jia, Paul M. Armenta, Ashley White-Stern, Yichun Fu, Zoë Blake, Bret Taback, Basil A. Horst, Yvonne M. Saenger, Steven Leonardo, Keith Gorden, Ross B. Fulton, Kathryn Fraser, Takashi Kangas, Richard M. Walsh, Kathleen Ertelt, Jeremy Graff, Mark Uhlik, Jennifer S. Sims, Takashi Tsujiuchi, Jeffrey N. Bruce, Peter Canoll, Anthony W. Tolcher, Evan Alley, Gurunadh R. Chichili, Jan E Canoll, Paul A. Moore, Ezio Bonvini, Syd Johnson, Sadhna Shankar, James R. Vasselli, Jon M. Wigginton, John D. Powderly
Bibliographic record
VenueJournal for ImmunoTherapy of Cancer · 2016
Typearticle
Languageen
FieldMedicine
TopicCancer Immunotherapy and Biomarkers
Canadian institutionsColumbia CollegeUniversity Health NetworkPrincess Margaret Cancer CentreUniversité Laval
FundersNational Center for Advancing Translational Scienceslékařská fakulta Univerzity KarlovyRadboud Universitair Medisch CentrumUniversité Paris DescartesEMD SeronoKindai UniversityRadboud UniversiteitKarolinska InstitutetInstitut National de la Santé et de la Recherche MédicaleUniversité Pierre et Marie CurieDr. Ralph and Marian Falk Medical Research TrustSidra MedicineGraduate School, University of MarylandPennsylvania Department of HealthUniversity of BernUniverzita Karlova v PrazeNational Cancer InstituteAlliance for Cancer Gene TherapyNational Institutes of HealthKeio UniversityNational Science Foundation
KeywordsDurvalumabLung cancerCD8ImmunotherapyCancer immunotherapyOncologyMedicineCancer researchInternal medicineCancerImmunologyImmune systemNivolumab
Abstract
### O1 Combinatorial CD8+ and PD-L1+ cell densities correlate with response and improved survival in non-small cell lung cancer (NSCLC) patients treated with durvalumab #### Sonja Althammer1, Keith Steele2, Marlon Rebelatto2, Tze Heng Tan1, Tobias Wiestler1, Guenter Schmidt1, Brandon Higgs2, Xia
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.355
Threshold uncertainty score0.709
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.018
GPT teacher head0.319
Teacher spread0.301 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations17
Published2016
Admission routes1
Has abstractyes