December 2016 at a Glance: Cardiac Metabolism, Myocarditis, Right Ventricular Function and Prognostic Markers
Bibliographic record
Abstract
Cardiac metabolismAlthough the heart is one of the main energy consuming organs of the body and despite the profound changes in its metabolism in the failing heart, cardiac metabolism has been seldom considered as a potential treatment target.A major change in the cardiac metabolism occurs in the failing heart with the main source of ATP production shifting from fatty acid oxidation to the more efficient glucose oxidation and, then, to the far less efficient anaerobic glycolysis.Changes in myocardial metabolism may contribute to the impairment in contractility and heart failure (HF) progression.Many drugs may have potential beneficial effects on myocardial energy production and improve cardiac contractility.As outlined in the review by Heggermont et al. they may act through blockade of fatty acid oxidation, stimulation of glucose oxidation or through indirect approaches such as the increase in calcium reuptake or stronger actin myosin cross-bridge formation or better mitochondrial energy production. 1
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.002 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.023 | 0.010 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".