LATE-BREAKING ABSTRACT: Sphingolipids in tracheal aspirates of prematurely born infants with and without BPD
Bibliographic record
Abstract
Background: We previously showed that sphingolipids, in particular ceramides, played a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a target for therapeutic intervention in a mouse model. Aims and objectives: To determine whether ceramides are detectable in tracheal aspirates (TAs) of prematurely born infants and to investigate whether ceramide profiles can predict the development of BPD. Methods: Infants born ≤ 32 weeks of gestational age (GA) in need for mechanical ventilation in the first week of life were included. TAs were obtained directly after intubation, and at day 1, 3, 5, 7, and 14. Ceramide levels were measured by liquid chromatography tandem mass spectrometry. BPD was defined as ≥ 28 days supplemental oxygen at 36 weeks postmenstrual age (PMA). Results: 122 infants were included (median GA (25-75th centile): 27.2 (25.6-29.6) weeks, median birthweight (25-75th centile): 967.5 (700.0-1263.8) gram). Fourteen infants died before 36 weeks PMA and 42 infants developed BPD. Infants with BPD had significantly higher concentrations of several ceramides at day 0, 5, 7 and 14. Conclusion: Ceramides were detectable in TAs of prematurely born infants and differed between infants with and without BPD. This confirms our observations in a mouse model, and suggests that ceramides are playing a role in the pathogenesis of BPD and might be a new target for therapeutic intervention.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".